Therapies Targeting Mucosal Eosinophils in Eosinophilic Gut Diseases From Esophagus to Colon

A subtle increase in eosinophils has also been observed in other GI diseases including functional dyspepsia in the duodenum. Targeted drug therapy can markedly reduce eosinophil infiltration, although symptom response is more variable, suggesting that non–eosinophil pathways play a role in pathogenesis.