Acroosteolysis dominant type

Acroosteolysis dominant type is a rare connective tissue disorder and belongs to a group of several osteolytic diseases. 

Acroosteolysis dominant type characterized mainly by a stunted growth, a progressive loss of end-phalanges, a progressed osteoporosis and a crowded carpalia. Facial features are also prominent, including prominent eyebrows and eyelashes, low-set ears and a broad nose. 

Other symptoms vary in each patient. 

The disease manifests in childhood, but a correct diagnosis is usually made later, since the first symptoms are nonspecific. 

The genetic cause of the syndrome has not been cleared so far. 

The prognosis varies greatly. Life threatening symptoms include the presence of a basilar compression.