Hemophilia A is a hereditary disease, in which the blood coagulation is disturbed due to a lack of coagulation factor VIII. The lack of the coagulation factor can be partial or complete, which determines the severity of the disease.
The disease is inherited as an X-chromosomal recessive trait, because of which mainly male patients are affected. Main symptoms in those affected include repeatedly reoccurring external and internal bleeding, which in the worst case can lead to death.
Most common symptoms include joint and muscle bleeding (due to repeated high pressure applied to these body parts) and spontaneous hematomas.
In addition to hemophilia A, there is another form of a hereditary type of hemophilia, hemophilia B, in which case coagulation factor IX is missing.