Reardon-Hall-Slaney syndrome

Reardon-Hall-Slaney syndrome is a very rare, autosomal recessive disease and is one of the mesomelic dysplasias. The disease manifests in the neonatal period and is particularly marked by a mesomelic (especially forearm and lower leg) glaucoming and ulceration of the limbs.

Associated with this is the formation of skin buds. Other characteristic features are camptodactyly (fixed flexion contracture of a finger, usually of the small or the ring finger), cleft palate with retrogenia and hypoplastic mandible.

Reardon-Hall-Slaney syndrome has been described in a pair of siblings (a girl and a boy). These had consanguine parents. The sister died of cardiopulmonary arrest a few hours after birth and the brother lived until the age of 4 years.

There is no known causal therapy.