X-linked lissencephaly with abnormal genitalia

XLAG syndrome is an X-linked lissencephaly with abnormal genitalia. It is a severe neurological condition that affects only men, leading to severe epilepsy and dysfunction of the hypothalamus.

Other clinical features include corpus callosum agenesis, lissencephaly, and intermediate genitalia with micropenis and cryptorchidism.

The cause of sydrome may be a mutation in the X-linked ARX gene.