Conventional therapies for constipation aim to improve bowel motility or secretion. But many sufferers do not achieve the desired success with these treatment options. In addition, there are possible side effects of pharmacological therapy.
Experts in the field of intestinal peristalsis and constipation have therefore conducted a multicentre, randomised phase III study in which they investigated the effect of the vibrating capsule. This effect is said to be achieved by stimulating the intestinal peristalsis and the body's own intrinsic biorhythm. Thus, it could represent a non-drug treatment for chronic constipation.
Operation and handling of the product are simple - patients swallow the capsule in the evening and activate the vibrations externally the next day. In the study, the vibrating capsule was taken five days a week over a period of eight weeks. Activation was either at 2pm or 6am - with the afternoon schedule giving slightly better results.
The shock waves last three seconds and are followed by a 16-second pause. This rhythm takes place over two hours. The capsule is then excreted with the stool.
Compared to the placebo group, statistically significant improvements were achieved for the study participants in the capsule arm:
The researchers assume that the good efficacy is associated with the imitation and support of the natural body rhythm. They also emphasise that there were no increased side effects during treatment with the vibration capsule - on the contrary: the therapy was well tolerated. However, about 11 % of the study participants reported being able to feel the shock waves.
The new vibrating capsule could be an attractive treatment option for people with chronic constipation. Although the therapy was well tolerated in the study, taking a capsule is not suitable for all patients - especially those who have already had bowel surgery or have narrowing of the lumen should avoid taking it. FDA approval is expected for the end of 2022; when and whether this will also happen for Germany remains to be seen.