Interleukin-6 (IL-6) Blockade improves glycemic control in rheumatoid arthritis patients

In a post hoc analysis of two phase 3 trials, therapy with Sarilumab lowered HbA1c concentrations in diabetic and nondiabetic rheumatoid arthritis (RA) patients.

Effects of Sarilumab in glycated hemoglobin observed

In a post hoc analysis of two phase 3 trials, therapy with Sarilumab lowered HbA1c concentrations in diabetic and nondiabetic rheumatoid arthritis (RA) patients.

Patients with rheumatoid arthritis have a higher risk of diabetes of up to 25%. IL-6 can play a role in this, as it is involved in glucose metabolisms and has been identified as an independent risk factor for diabetes. “With this in mind we conducted a post hoc analysis of two phase 3 trials, ‘mobility’ and ‘target’”, said Professor Mark Genovese from the Stanford School of Medicine, USA.

Patients with baseline and at least one post-baseline blood sample were included in this analysis and categorized as diabetic or non-diabetics based on a medical history of diabetes or prior use of antidiabetic medication. Changes from baseline in fasting glucose, HbA1c, and weight were analyzed with a linear regression model.

Mean fasting glucose and HbA1c at baseline were similar across treatment groups, but higher in the diabetes group than in the non-diabetes group. Decreases in HbA1c occurred in all patients treated with Sarilumab. “In diabetic patients, curves diverged at week 12, but interestingly, we see the same trend in non-diabetics”, said Prof. Genovese. Changes of HbA1c were independent of baseline oral glucocorticoid use or clinical response to treatment with Sarilumab. “We do see improvements and I think they have clinical relevance: IL-6 signaling interruption might be the cause”, concluded Prof. Genovese.

Therefore, a fully designed diabetic study might be of interest to fully understand the effect of Sarilumab in these patients.

Genovese, M.C. et al. Combination with DMARDs on Fasting Glucose and Glycosylated Hemoglobin in Patients with Rheumatoid Arthritis With and Without Diabetes. Abstract No 1822, 2017 ACR/ARHP Annual Meeting, November 3- 8 2017, San Diego (CA/USA).

Esanum is an online network for approved doctors

Esanum is the medical platform on the Internet. Here, doctors have the opportunity to get in touch with a multitude of colleagues and to share interdisciplinary experiences. Discussions include both cases and observations from practice, as well as news and developments from everyday medical practice.

Esanum ist ein Online-Netzwerk für approbierte Ärzte

Esanum ist die Ärzteplattform im Internet. Hier haben Ärzte die Möglichkeit, mit einer Vielzahl von Kollegen in Kontakt zu treten und interdisziplinär Erfahrungen auszutauschen. Diskussionen umfassen sowohl Fälle und Beobachtungen aus der Praxis, als auch Neuigkeiten und Entwicklungen aus dem medizinischen Alltag.

Esanum est un réseau en ligne pour les médecins agréés

Esanum est un réseau social pour les médecins. Rejoignez la communauté et partagez votre expérience avec vos confrères. Actualités santé, comptes-rendus d'études scientifiques et congrès médicaux : retrouvez toute l'actualité de votre spécialité médicale sur esanum.