- Northuis C, Bell E, Lutsey P, George KM, Gottesman RF, Mosley TH, Whitsel EA, Lakshminarayan K. Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study. Neurology. 2023 Aug
In recent years, several studies have focussed on the possible link between the use of PPIs and the incidence of dementia. There are no clear results to date. The cumulative use of proton pump inhibitors and their influence on neurodegenerative diseases has also hardly been researched to date. A recent study has published data on this topic.
The study analysed data from over 5,500 people who had been taking PPIs for a long period of time. Interestingly, prolonged use was defined as at least 112 days and a maximum of over 20 years. After a five-year follow-up, it was analysed whether the use of acid inhibitors was associated with an increased risk of dementia.
The study authors came to the conclusion that long-term use of proton pump inhibitors does not appear to lead to an increased incidence of dementia. However, the study data also suggest that this may no longer be true for use over 4.4 years. In the study population, the risk of dementia increased by 33% under this condition. Further studies are needed to confirm the results and understand the correlations.
In this study, the medium to long-term use of PPIs was not generally associated with an increased risk of dementia. However, taking the medication over several years could increase the incidence of neurodegenerative diseases. This hypothesis, which is based on the data obtained in this study, should be further researched and evaluated.