Prostatectomy: R-LRPE better than LRPE for continence

New findings from the first prospective, multicenter, randomized trial demonstrated improved continence for patients undergoing robotic-assisted radical prostatectomy as compared with conventional laparoscopic radical prostatectomy.

The post-surgery assessments will continue until 36 months

New findings from the first prospective, multicenter, randomized trial demonstrated improved continence for patients undergoing robotic-assisted radical prostatectomy as compared with conventional laparoscopic radical prostatectomy.

Prof. Jens-Uwe Stolzenburg (University of Leipzig, Germany) presented the results of the LAP-01 study, which aimed to generate conclusive data supporting improved continence after robotic-assisted radical prostatectomy (R-LRPE) in a prospective setting in four German centers1.    

Patients (at data cut-off, n=713) were randomized 3:1 to either robotic-assisted (n=527) or conventional laparoscopic radical prostatectomy (LRPE; n=186). Patients were blinded to their arm allocation until month 3. The primary endpoint of the study was continence restoration at month 3, as defined by not requiring a pad for 3 or more consecutive days. Post-operative follow-up will be continued for 3 years, with assessments planned for 1, 3, 6, 12, 24, and 36 months. Prof. Stolzenburg presented the data for up to 12 months. 

Overall, complication rates were lower in patients who received robotic surgery. Perioperative outcomes were comparable between both arms, including nerve-sparing rates, prostate size/weight, margin status, pathological tumor stage, duration of surgery, and duration of catheterization. However, the primary endpoint was met and continence rates among the patients treated robotically were significantly higher at 3 months (P=0.00064), 6 months (P=0.004), and 12 months (P=0.044). Continued follow-up will determine the longer-term effects. 

Reference:
1. Stolzenburg J-U, et al. Continence Following Robot-Assisted (R-LRPE) and Conventional Laparoscopic Radical Prostatectomy (LRPE) – Results of a Prospective, Randomized, Multicenter, Patient Blinded Study. EAU20 Virtual Congress, 17-26 July 2020, Game-Changing Session 1.

Esanum is an online network for approved doctors

Esanum is the medical platform on the Internet. Here, doctors have the opportunity to get in touch with a multitude of colleagues and to share interdisciplinary experiences. Discussions include both cases and observations from practice, as well as news and developments from everyday medical practice.

Esanum ist ein Online-Netzwerk für approbierte Ärzte

Esanum ist die Ärzteplattform im Internet. Hier haben Ärzte die Möglichkeit, mit einer Vielzahl von Kollegen in Kontakt zu treten und interdisziplinär Erfahrungen auszutauschen. Diskussionen umfassen sowohl Fälle und Beobachtungen aus der Praxis, als auch Neuigkeiten und Entwicklungen aus dem medizinischen Alltag.

Esanum est un réseau en ligne pour les médecins agréés

Esanum est un réseau social pour les médecins. Rejoignez la communauté et partagez votre expérience avec vos confrères. Actualités santé, comptes-rendus d'études scientifiques et congrès médicaux : retrouvez toute l'actualité de votre spécialité médicale sur esanum.