Risk factors for severe COVID-19 among IBD patients

TNF antagonists do not appear to be associated with severe COVID-19, a large, international registry to monitor outcomes of IBD patients with confirmed COVID-19 found.

Increasing age, comorbidities, and corticosteroids are associated with severe COVID-19 among IBD patients. Notably, TNF antagonists do not appear to be associated with severe COVID-19. That was found in a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19, called SECURE-IBD.

The impact of COVID-19 on patients with inflammatory bowel disease (IBD) is not well characterized. The SECURE-IBD survey characterized the clinical course of COVID-19 among IBD patients and evaluated the association between demographics, clinical characteristics, and immuno-suppressant treatments on COVID-19 outcomes.

Case fatality rate

Reported were 959 COVID-19 cases from 40 countries (median age 43 years, 52% men). Of those, 86 patients (9%) had severe COVID-19, 320 (33%) were hospitalized, and 37 patients died (3.9% case fatality rate). Age-standardized mortality ratios (SMRs) for IBD patients were:

Risk factors

Furthermore, the investigators aimed to identify factors associated with severe COVID-19, defined as intensive care unit admission, ventilator use, and/or death, using multivariable logistic regression.

Risk factors found for severe COVID-19 among IBD patients in the current study included:

In contrast, TNF antagonist treatment was not associated with severe COVID-19 (aOR 0.9).

The SECURE-IBD registry showed an association between increasing age, comorbidities, and corticosteroids and severe COVID-19 among IBD patients. Nevertheless, no association was found for TNF antagonists with severe COVID-19.

Source:
1. Ungaro R. Impact of COVID-19 on patients with inflammatory bowel disease: data from an international registry. UEG Week Virtual Symposium 2020, abstract OP153.

Esanum is an online network for approved doctors

Esanum is the medical platform on the Internet. Here, doctors have the opportunity to get in touch with a multitude of colleagues and to share interdisciplinary experiences. Discussions include both cases and observations from practice, as well as news and developments from everyday medical practice.

Esanum ist ein Online-Netzwerk für approbierte Ärzte

Esanum ist die Ärzteplattform im Internet. Hier haben Ärzte die Möglichkeit, mit einer Vielzahl von Kollegen in Kontakt zu treten und interdisziplinär Erfahrungen auszutauschen. Diskussionen umfassen sowohl Fälle und Beobachtungen aus der Praxis, als auch Neuigkeiten und Entwicklungen aus dem medizinischen Alltag.

Esanum est un réseau en ligne pour les médecins agréés

Esanum est un réseau social pour les médecins. Rejoignez la communauté et partagez votre expérience avec vos confrères. Actualités santé, comptes-rendus d'études scientifiques et congrès médicaux : retrouvez toute l'actualité de votre spécialité médicale sur esanum.