Esanum is the medical platform on the Internet. Here, doctors have the opportunity to get in touch with a multitude of colleagues and to share interdisciplinary experiences. Discussions include both cases and observations from practice, as well as news and developments from everyday medical practice.
esanum ist die Ärzteplattform im Internet. Hier haben Ärzte die Möglichkeit, mit einer Vielzahl von Kollegen in Kontakt zu treten und interdisziplinär Erfahrungen auszutauschen. Diskussionen umfassen sowohl Fälle und Beobachtungen aus der Praxis, als auch Neuigkeiten und Entwicklungen aus dem medizinischen Alltag.
Esanum est la plate-forme médicale sur Internet. Ici, les médecins ont la possibilité de prendre contact avec Une multitude de collègues et de partager des expériences interdisciplinaires. Les discussions portent à la fois sur les Observations de la pratique, ainsi que des nouvelles Et les développements de la pratique médicale quotidienne.
Based on the available scientific knowledge and pre-clinical evidence, the University of Massachusetts Medical School has initiated multicenter, phase I clinical trial to investigate an HIV vaccine that might prevent HIV infection.
Despite the publication of several promising strategies, fewer vaccine candidates have been investigated in human clinical trials, until this date.
The synthetic DNA vaccine has been developed by Dr. Shan Lu, MD, Ph.D., Professor of Medicine and Biochemistry & Molecular Pharmacology at the University of Massachusetts (UMass). In the study, researchers want to harness the power of DNA vaccines by inducing the pathogenic antigen-specific immune response against HIV.
This vaccine has been designed by using limited DNA sequences of HIV to induce an immune response, followed by a booster protein vaccine mimicking the viral DNA proteins.
Kickstarted in 2018, the clinical trials are being conducted by the researchers at the HIV Vaccine Trials Network. The early study will enroll healthy subjects who are at low-risk of acquiring HIV, and the participants will receive frequent counseling for HIV prevention at four clinical trial sites.
In the Phase I-clinical trial, the safety and tolerability of the experimental vaccine are to be investigated, over 6 to 12 months. The double-blinded study involves two groups of participants; one group has been assigned to receive the protein vaccine combined with an adjuvant GLA-SE to boost the immune response, whereas the comparator group participants are assigned to receive the DNA and protein vaccines, simultaneously. The aim of this study design is to ascertain the efficacy/immunogenicity of both DNA and protein vaccines via induction of cell-mediated immune response and antibody activation against HIV pathogen.
The researchers have developed a prime-boost method that is capable of producing antibodies against several viral antigens. Upon vaccination, the vaccine prompts the B-lymphocytes to produce the HIV antigen-specific antibodies. With the combined power of prime and boost vaccines, the induced-antibodies target the Achilles' heel of HIV effectively, and the induced immune response/efficacy may persist for years.