- Kim DW, Byun JM, Lee JO, Kim JK, Koh Y. Chemotherapy delivery time affects treatment outcomes of female patients with diffuse large B cell lymphoma. JCI Insight. 2023 Jan 24;8(2):e164767. doi: 10.1172/jci.insight.164767. PMID: 36512421
The Korean researchers compared the outcomes of morning and afternoon administration of R-CHOP in patients with DLBCL. They found that administering the therapy later in the day was associated with better outcomes in women. This is not the case for men.
For example, the data show that morning administration of chemotherapy was associated with significantly shorter progression-free survival and overall survival - but only for women. However, afternoon administration of therapy not only improved survival, but patients also had significantly fewer infections or febrile neutropenias.
Why do women respond better to therapy in the afternoon? The better effect of chemotherapy in the afternoon could be related to the circadian fluctuations of leukocytes and neutrophils, the researchers say. These fluctuations are more pronounced in women than in men.
Afternoon chemotherapy can be associated with significantly better outcomes for DLBCL patients. In addition, the data from the current study showed that the timing of treatment was also associated with fewer complications and side effects.
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