• Only modest benefit of colon cancer screening with colonoscopy

    A one-time colonoscopy for screening entailed an 18% risk reduction of incidence in colorectal cancer (CRC) compared with no screening.

  • Procalcitonin-based algorithm helps spare antibiotics in acute pancreatitis

    Both antibiotic use and days with antibiotic use could be markedly reduced with the help of a procalcitonin-based algorithm.

  • Is early surgery an underestimated treatment in patients with limited CD?

    Early surgery might benefit Crohn's patients, but identifying exact patient groups who will benefit from early surgery requires prospective studies.

  • Adenoma detection rates augmented by AI in colonoscopy

    Compared to conventional colonoscopy, the addition of artificial intelligence entailed significantly higher detection and lower rates of missed adenomas.

  • Mirikizumab shows sustained maintenance of symptom remission in ulcerative colitis

    Symptom control maintenance after 40 weeks was investigated in mirikizumab responders after a 12 week induction therapy.

  • H. pylori eradication protects against ulcer bleeding in aspirin users

    Significantly less ulcer bleeding was found in patients with chronic aspirin use who underwent eradication of Helicobacter pylori, according to HEAT trial results.

  • Light at the end of the tunnel for children with eosinophilic oesophagitis

    In the phase 3 EoE KIDS trial, dupilumab showed remarkable efficacy in paediatric patients with eosinophilic oesophagitis.

  • Longitudinal microbiome changes hold diagnostic value

    For the first time, a study assessed longitudinal changes in microbiota during therapy with immune checkpoint inhibitors (ICIs).

  • Postponed drainage beneficial with infected necrotising pancreatitis

    Follow-up >6 months for necrotising pancreatitis infections with immediate or delayed drainage showed no influence on mortality or major complications.

  • Additional clinical benefit of risankizumab in patients with delayed response

    Crohn's patients who responded only after a risankizumab second induction kept a CDAI clinical response in 75.8% on subcutaneous 360 mg at week 52.

  • Upadacitinib shows fast onset of action and high efficacy in CD

    Upadacitinib led to remission rates and endoscopic response in almost half of intensively pretreated patients with moderate-to-severe Crohn's at week 12.

  • Alarmingly low detection rates of pancreatic cancer

    A study revealed that pancreatic cancer was initially missed in CT or MRI scans in 7.7% of the affected patients, reducing chances of curative surgery.

  • The high price of digestive diseases

    A new Europe-wide study highlights the worrying increase in the prevalence of various digestive diseases since 2000.

  • Does a larger dose interval of adalimumab maintenance work in CD?

    Maintenance therapy with an higher dose interval of adalimumab resulted in similar persistent flare rares in Crohn's Disease patients in stable remission.

  • ESD: A gamechanger in colorectal lesions?

    Though widely used in Japan, in Europe its application has been on the rise in recent years: How can colorectal ESD help in gastroenterology?

  • Update: Etrasimod’s effect on immune cells in UC

    Etrasimod leads to significant reductions in T and B cell subsets and paralleled reductions in absolute lymphocyte counts, showed the ELEAVATE trials.

  • Defeating Helicobacter pylori: Mission impossible?

    H. pylori is considered the main cause of gastric cancer. If we eradicate it, other stomach-related diseases may become rarer. Are we close to achieving this?

  • Final results support upadacitinib as maintenance therapy in UC

    +52 weeks of upadacitinib therapy for ulcerative colitis outperformed placebo in endpoints like clinical, histological, and patient-reported outcomes.

  • Better transplant-free survival for colectomy with ileostomy in PSC patients

    Primary sclerosing cholangitis patients who received colectomy with ileostomy had a higher survival chance without liver transplant than those without surgery.

  • Mirikizumab improves histologic and endoscopic signs of inflammation in UC

    Therapy with mirikizumab leads to a higher percentage of patients achieving resolution of active colonic inflammation with absence of neutrophils at induction.

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