• Link between genital warts and the HLA system might lead to new therapeutic targets

    A study linked genital warts and human leukocyte antigen systems. Protective and risk alleles could be identified as future antiviral or vaccine targets.

  • JAK3 blockade leads to long-term improvement in non-segmental vitiligo

    A dose-ranging study showed that oral treatment with the JAK3 inhibitor ritlecitinib is efficacious in reducing depigmented areas in the face.

  • Topical ruxolitinib: A valid option for older patients with atopic dermatitis

    A elderly-focused subanalysis of phase 3 trials revealed IGA-TS in 60.5% of atopic dermatitis patients applying 1.5% ruxolitinib cream over 8 weeks.

  • Considering psychiatric comorbidities in cardiac and addictive diseases

    What influence do cardiological, social or neurological problems have on psychiatric diseases and vice versa? This question was addressed by the speakers at the symposium "Recognising and treating psychiatric comorbidities".

  • JAK1 inhibitor beats dupilumab in fast itch control in atopic dermatitis

    A trial showed abrocitinib superiority over dupilumab in fast itch control and skin clearance in adult patients with moderate-to-severe atopic dermatitis.

  • Tapinarof cream provides durable benefit for psoriatic patients

    A long-term assessment of topical tapinarof found a high rate of complete disease clearance as well as a lasting response up to 52 weeks.

  • JAK inhibition shows promising results in the treatment of alopecia areata

    Ritlecitinib was able to induce regrowth of hair in the ALLEGRO study. The effect was seen even in patients with alopecia universalis.

  • Ruxolitinib cream effective in non-segmental vitiligo

    Two phase 3 trials have demonstrated the efficacy of the topical JAK1/JAK2 inhibitor ruxolitinib in the therapy of vitiligo. The cream was well tolerated.

  • Physician-patient, a relationship in crisis

    The physician-patient relationship has been going through a profound crisis for years, with consequences not only for individual health but also for public health. We met with Prof. Fabrizio Asioli to talk about the issue.

  • TYK2 inhibitor shows impressive durability of response in psoriasis

    The once-daily deucravacitinib showed maintenance of response through week 52 in phase 3 POETYK PSO-1 and POETYK PSO-2 trials.

  • Infection risk is no discriminating factor when choosing between biologics

    A registry study revealed no differences in respiratory tract infections risks across biologics, including the newer IL-17 and IL-23 inhibitors.

  • Bruton’s tyrosine kinase inhibition: A new target in chronic spontaneous urticaria

    Remibrutinib showed promise with early-onset and further maintained action in chronic spontaneous urticaria, with many reaching a well-controlled disease.

  • Switching from dupilumab to upadacitinib leads to superior EASI scores in AD

    A trial that compared upadacitinib with dupilumab in adults with moderate-to-severe AD demonstrated benefits in shifting to the inhibitor.

  • OX40: A novel treatment target in atopic dermatitis

    In a phase 2a atopic dermatitis study, maintenance of response continued for months after last dose; this may hint at an option for extended medication intervals.

  • Letter to a young emergency physician

    Advice, words of encouragement and ideas for self-care from an experienced emergency physician to the younger generation.

  • Heterologous vaccination and Delta variant

    The results of a preliminary study suggest the efficacy of heterologous anti-COVID vaccination not only for the completion of vaccination but also for a possible "third dose".

  • Alcoholism: News about psychedelic therapy applications

    Researchers found molecular alterations in alcoholism causing impaired executive control and alcohol craving. Preclinical research showed psychedelics restored molecular deficits and reduced relapse behaviour.

  • Study on the effects of DMT in a natural environment

    A study by the University of Buenos Aires suggests the importance of investigating the effects of psychedelic drugs in the contexts in which they are naturally consumed, in order to obtain less artificial results.

  • Lay responders can save lives in out-of-hospital cardiac arrest

    Dispatching the public via an app as lay responders has shown to be accompanied by a 28% higher survival in patients with out-of-hospital cardiac arrest.

  • Impaired response to pneumococcal vaccine in children with RRIs

    Paediatric patients with RRI and/or chronic cough (CC) have a higher incidence of impaired response to PCV13 compared with the general population.

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