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Human papillomaviruses play an important role in the development of genital warts and the far more dangerous cervical carcinoma. There are well over 140 different HPV types, of which around 40 can infect the anogenital region.
Safety was as expected based on earlier experience with the agent in psoriasis, psoriatic arthritis (PsA), and Crohn’s disease (CD). Based on these results, ustekinumab may have the potential to offer a new treatment option for patients with SLE.
The intestinal immune system must constantly maintain the difficult balance between fighting infections and simultaneously tolerating harmless or useful germs, and our food components.
A recent data analysis of 78 clinical trials of adalimumab demonstrated an overall safety profile consistent with previous findings and the tumor necrosis factor (TNF) inhibitor class.
There are many type 1 diabetes patients who, despite insulin therapy, have poor metabolic control and high HbA1c values. This is often due to increased insulin resistance, which requires high doses of insulin. Could the additional oral administration of metformin be an option?
The largest routine care study of rituximab use in systemic sclerosis (SSc) patients showed significant changes in skin fibrosis but not in lung fibrosis.
The study of mice, published in Nature Communications, led to the discovery that the O-linked N-acetylglucosamine transferase (OGT) molecule sets sex-specific patterns of gene expression.
Apremilast has demonstrated sustained and clinically meaningful improvements in signs and symptoms of psoriatic arthritis, as well as in physical function in patients who continued treatment over 5 years.
A large, ongoing USA study with over 1.5 million cases analyzed lifestyle factors on tumorous cancer risk. The findings hint at how many cancer cases could be prevented with simple lifestyle changes.
Hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis surgery does not improve survival and may increase the rate of complications compared to surgery alone.
New research exposes that the human leukemia virus (HTLV-1) disrupts the regulation processes of thousands of genes and changes intracellular DNA loops, raising the risk of a rare type of leukemia.
A combination therapy with aspirin and low-dose rivaroxaban appears to be more effective in the secondary prevention of cardiovascular events than aspirin monotherapy.
With a modified folfirinox regimen, patients with non-metastatic pancreatic ductal carcinoma in adjuvant chemotherapy achieved a survival of 54.5 months compared to the previous gemcitabine standard of 35 months.
Recent data has shown that once-daily oral 4 mg of baricitinib for patients with systemic lupus erythematosus (SLE) who receive standard background therapy, is associated with significant clinical improvements compared to placebo.
Immunotherapy with the PD1 inhibitor pembrolizumab acts as first-line therapy in patients with advanced NSCLC and PD-L1 expression ≥ 1% better than standard chemotherapy. Patients lived 4 to 8 months longer in the median, with fewer side effects.
The results of a Scottish cluster-randomized study on Type-2 diabetes indicate that the illness could be reversed without anti-diabetic medicines.
Biosimilars use has taken off in the past few years and is expected to increase further. Recent findings add to the increasing evidence that switching from originator to bDMARDs is safe and efficacious.
Blue-181 molecule acts on spinal cord pain receptors instead of the brain, and arguably produces no narcotic or addiction side effects
Treatment with sunitinib alone was not inferior to nephrectomy followed by sunitinib in patients with advanced renal cell carcinoma and intermediate to high risk in effect on overall survival.
Dose-related NSAIDs with TNFi use in ankylosing spondylitis patients have a synergistic effect in slowing radiographic progression. The greatest effect is seen in those using both high-dose NSAIDs and TNFi.