• Guar gum alleviates IBS-related constipation in randomised-controlled trial

    Partially hydrolysed guar gum (PHGG) appeared to be efficacious in patients with irritable bowel syndrome-associated chronic constipation.

  • An accelerated treatment approach may save lives in pancreatic walled-off necrosis

    An accelerated treatment algorithm appeared to benefit patients with large pancreatic WON in terms of length-of-stay in the hospital and major complications.

  • Medical Case: A fever of unknown origin

    A 66-year-old patient enters the ER with persistent fever, night sweats and significant weight loss. He is admitted with the diagnosis of “persistent bronchopneumonia”...

  • Is FMT a viable option to treat primary C. difficile infections?

    A study found faecal microbiota transplantation was safe and non-inferior to vancomycin in patients with primary Clostridioides difficile infections.

  • CULTIVATE: Good signal for etrasimod in Crohn’s disease

    Etrasimod was associated with favourable outcomes and tolerability in patients with moderately to severely active CD in a phase 2 trial extension.

  • Malabsorption - key concepts and clinical approaches

    Key issues were discussed at the UEG Week related to current approaches to diagnostics, treatment and practical takeaways of malabsorption syndromes.

  • Mistakes in Lower GI: insights from UEG Week 2024

    A special congres session took a critical look at common errors in the management of lower gastrointestinal conditions, providing insights for clinical practice.

  • From guidelines to clinical practice: HPB

    Hepatobiliary and disease guidelines and updates were discussed during a session on prancreas-related cancer, exocrine insufficiency, cysts, and NASH.

  • Familial hidradenitis suppurativa associated with higher metabolic diseases risk

    A meta-analysis showed that HS familial cases are associated with higher cardiovascular diseases, hyperlipidaemia, and diabetes mellitus risk.

  • Deuruxolitinib significantly improves hair satisfaction in alopecia areata

    Post-hoc analysis of the THRIVE-AA1 and THRIVE-AA2 trials showed satisfaction in the THRIVE-AA1 and THRIVE-AA2 trials as early as week 12.

  • JAK1 inhibitor shows promising long-term efficacy in PN

    Povorcitinib led to a sustained reduction of pruritus and skin lesions in prurigo nodularis in a randomised-controlled phase 2 study.

  • HS: Bimekizumab shows sustained 2-year efficacy

    Continuing bimekizumab for 2 years led to maintenance of various HiSCR and International Hidradenitis Suppurativa Severity Score System (IHS4) scores.

  • Second-generation selective PDE-4 inhibitor shows promise in AD

    Orismilast demonstrated higher rates of Investigator Global Assessment of 0/1 at week 16 compared with placebo in the phase 2b ADESOS trial.

  • Delgocitinib cream outperforms oral alitretinoin in chronic hand eczema

    A comparison of topical delgocitinib with systemic alitretinoin for treating patients with chronic hand eczema (CHE) favoured the pan-JAK inhibitor.

  • PsoBest registry: Biologics have become the first choice in moderate-to-severe psoriasis

    A comprehensive analysis from the German Psoriasis Registry (PsoBest) highlights the evolution of systemic drug use for psoriasis over the past 15 years.

  • Topical pan-JAK inhibitor mitigates inflammatory biomarkers in frontal fibrosing alopecia

    Delgocitinib was associated with a reduction in interferon gamma (IFN-γ), chemokine ligand (CXCL)9, and CXCL10 in the treatment of FFA.

  • Atopic dermatitis early in life imposes a lifelong psychosocial burden

    A study including data from over 30,000 participants revealed that early onset of atopic dermatitis (AD) leads to a psychosocial burden throughout adult life.

  • Prurigo nodularis: long-term treatment reduces relapse events

    Withdrawing nemolizumab led to an 8-fold increase in the likelihood of a prurigo nodularis (PN) relapse compared with uninterrupted therapy.

  • Autism: diagnosis through the eyes?

    A combination of eye-tracking tests could help to speed up the diagnostic process and make it more efficient, according to the authors.

  • Imsidolimab potential future therapeutic avenue for generalised pustular psoriasis

    A single dose of 750 mg imsidolimab yielded a GPPPGA score of clear or almost clear in over half of the participants with GPP after 4 weeks.

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