• Standards of Care in transgender medicine

    In transgender and gender-diverse medical care, gynaecologists play a supporting role. How should this group of patients be treated? The WPATH published a standard-of-care document on the issue.

  • What will happen with COVID-19?

    Three years since the start of the pandemic, SARS-CoV-2 faces the immunity that humans built up through vaccines and countless infections.

  • Baricitinib: a possible treatment option for children with AD?

    Children treated with various baricitinib dosages for atopic dermatitis showed significant amelioration with high dose in the BREEZE-AD-PEDS study.

  • Neoadjuvant pembrolizumab outperforms it as adjuvant in resectable melanoma

    Compared with the same treatment given entirely in the adjuvant setting, this application improves event-free survival in resectable stage III–IV melanoma patients.

  • Improved survival seen with pembrolizumab + CRT in locally advanced head-and-neck SCC

    First-line pembrolizumab plus chemoradiotherapy shows favourable trend to improved EFS in locally advanced head and neck squamous cell carcinoma.

  • The fear of bladder stones

    Which pain was worse? A renal colic or the removal of urinary calculus? Whoever did it needed to master the technique and understand the patient.

  • Iran: Calls to save a doctor sentenced to death

    Dr Hamid Ghareh-Hassanlou and his wife Farzaneh were convicted after a trial on 30 November. The radiologist is now facing execution. International doctors and medical associations are now mobilising to prevent the execution.

  • Deuruxolitinib, a novel JAK inhibitor, proves effective in alopecia areata

    The inhibitor was highly effective in severe alopecia areata with a high % of satisfied or very satisfied patients.

  • A new biologic treatment for HS: secukinumab is on the doorstep

    Secukinumab achieved a clinical response in over 40% of hidradenitis suppurative patients and reduced abscesses and pain, and improved quality-of-life.

  • Preventing stress eating, and achieving weight targets

    Chronic stress releases cortisol. Studies show that this increases cravings for high-calorie, sweet, fatty and processed foods. A challenge for many overweight people.

  • PsoBest registry reveals: Genital psoriasis is often followed by sexual dysfunction

    An analysis of 811 surveys shows nearly half of psoriasis patients have psoriatic lesions around the genital region and other areas of sexual interest.

  • Medical emergencies: when music helps (Part 1/3)

    Are you a rock fan? According to a study, if "Highway to Hell" riffs at high volume in the operating theatre, there's a good prognosis!

  • Nalbuphine: another candidate for an approved treatment in prurigo nodularis?

    Significantly more patients on nalbuphine achieved at least a 4-point decrease on the worst itch (WI-) numeric rating scale (NRS), QoL rose, and skin lesions improved.

  • Sotorasib shows superior PFS and ORR over docetaxel in previously treated NSCLC

    Improvement seen in progression-free survival and ORR by the selective KRAS G12C inhibitor over docetaxel in previously treated KRAS G12C-mutated NSCLC.

  • Kappa-opioid receptor agonist shows remarkable efficacy in notalgia paresthetica

    Difelikefalin leads to rapid decrease in pruritus in notalgia paresthetica, a very common, underdiagnosed condition with a lack of treatment possibilities.

  • Selective IL-23 inhibitor shows long-term efficacy in active PsA

    KEEPsAKE 1 and 2 trials demonstrated high efficacy of the IL-23 blocker risankizumab in adult patients with active psoriatic arthritis independent of previous therapy.

  • Fern extract reverses UV induced cell damage and occurrence of new lesions

    A local and oral preparation of polypodium leucotomos extract led to clinical reversal of actinic keratosis lesions at 12 months.

  • When lightning strikes: tips for emergency management

    Dr. Robert McMickle, an emergency physician at Harbor UCLA Medical Center in Los Angeles, delves into the topic of lightning injuries.

  • Colonoscopy as a screening examination

    A trial on colonoscopy for colorectal cancer prevention showed that a physician invitation for a screening check-up reduced incidence but not mortality.

  • Roflumilast 0.3% foam beneficial in various aspects of seborrheic dermatitis

    A new study shows over 80% of primary endpoint reach of clear or almost clear skin, according to the Investigator's Global Assessment at week 8.

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