• AXIOMATIC-SSP trial: Reducing risks of ischaemic stroke with factor XIa inhibition?

    The trial showed that dose response was not observed, yet a 30% relative risk reduction was seen in symptomatic ischaemic strokes with milvexian.

  • Rheumatic heart disease-associated AF: standard-of-care holds ground

    In rheumatic heart disease-associated AF patients, VKAs therapy was non-inferior to rivaroxaban for a composite of cardiovascular events or death rates.

  • MIS-C in children after COVID-19: Origin in the gut?

    Multisystemic inflammatory syndrome can appear in children and adolescents as a consequence of SARS-CoV-2 infection.

  • The use of virtual reality in the physician-patient-relationship

    Surgery planning, education or even communication: Virtual and augmented reality give room to many applications in patient-physician interactions.

  • Allopurinol disappoints in ALL-HEART

    A prospective study showed that the medication did not reduce events, including non-fatal MI, non-fatal stroke, or cardiovascular death, in patients with IHD.

  • Positive results for subcutaneous pegozafermin in severe hypertriglyceridemia

    Treating severe hypertriglyceridaemia patients with subcutaneous pegozafermin significantly reduced triglycerides across all study dose groups.

  • Meta-analysis of DELIVER and EMPEROR-Preserved

    SGLT2 inhibitors reduced the risk of cardiovascular death and hospitalisation for heart failure across HFpEF/HFmrEF patient subgroups.

  • Medical therapy as good as PCI for ischaemic cardiomyopathy

    In severe ischaemic left ventricular systolic dysfunction patients, PCI did not reduce the composite incidence of all cause death or hospitalisation for heart failure.

  • "BOXing" out oxygen and blood pressure targets

    The BOX trial shows that outcomes of comatose patients after an OHCA are not affected by shifting targets of oxygenation or blood-pressure.

  • High-dose influenza vaccine: A mortality risk reduction?

    A high-dose vaccination (60 μg of haemagglutinin antigen) in older adults reduced death risk by 49% and hospitalisation by 64%, compared with standard-dose vaccination.

  • Therapy with proton pump inhibitors - when to continue, when to stop?

    PPIs should work against gastrointestinal complaints, but some patients need them permanently. Researchers have set therapy guidelines for this.

  • Acetazolamide + loop diuretics improves decongestion

    Adding acetazolamide to loop diuretics in ADHF patients with volume overload improved rates of successful decongestion within 3 days.

  • Danish study suggests starting CVD screening before age 70

    Results point to a screening target age below 70 years, for a substantial reduction of combined endpoints of death, stroke, or myocardial infarction.

  • Taking hypertension medication "anyTIME"

    The TIME trial reported that taking antihypertensives mornings or evenings, provides identical protection against heart attack, stroke, or vascular death.

  • First RCT evidence for use of AI in daily practice

    After blinded review of initial LVEF assessment, cardiologists were less likely to substantially change final reports with initial AI than sonographer assessment.

  • Polypill SECUREs win in secondary prevention in elderly

    The 'polypill' dose of aspirin, ramipril, and atorvastatin prevents secondary CV events in people ≥65 years old who previously had myocardial infarction.

  • Minimally invasive tumour treatment done via histotripsy

    Focused ultrasound waves can be used to destroy tissue with millimetre precision. The innovative technology is being tested in the 'HOPE4LIVER' study.

  • Trial results: dapagliflozin DELIVERs for HFmrEF/HFpEF

    Dapagliflozin reduced cardiovascular death risk or worsening heart failure in patients with mildly reduced and preserved ejection fraction.

  • Fears of neprilysin inhibition effects on cognition removed

    Trial results show no evidence that neprilysin inhibition raised cognitive impairment risk due to brain amyloid-β accumulation, for HFmrEF/HFpEF patients.

  • mRNA vaccines and broadly neutralising antibodies

    mRNA vaccines should induce viral proteins directly in the body and stimulate the immune system to produce broadly neutralising antibodies against HIV.

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