• H. pylori eradication protects against ulcer bleeding in aspirin users

    Significantly less ulcer bleeding was found in patients with chronic aspirin use who underwent eradication of Helicobacter pylori, according to HEAT trial results.

  • High maintenance rates for novel IL-13 inhibitor in AD

    Up to 80.6% of Phase 3 ADvocate trial responders, based on dosing interval, stayed clear or almost clear of lesions from weeks 16 to 52, according to the IGA scale.

  • Light at the end of the tunnel for children with eosinophilic oesophagitis

    In the phase 3 EoE KIDS trial, dupilumab showed remarkable efficacy in paediatric patients with eosinophilic oesophagitis.

  • IL4/IL13 blockade shows remarkable efficacy in prurigo nodularis

    A second phase 2 trial showed prurigo nodularis patients treated with dupilumab had a remarkable itch improvement from baseline to week 24.

  • Longitudinal microbiome changes hold diagnostic value

    For the first time, a study assessed longitudinal changes in microbiota during therapy with immune checkpoint inhibitors (ICIs).

  • Postponed drainage beneficial with infected necrotising pancreatitis

    Follow-up >6 months for necrotising pancreatitis infections with immediate or delayed drainage showed no influence on mortality or major complications.

  • What physicians should know about psychedelic therapy

    Drugs for mental health? That may still seem strange to some. We explain what physicians need to know about novel forms of therapy with psychedelic substances.

  • Additional clinical benefit of risankizumab in patients with delayed response

    Crohn's patients who responded only after a risankizumab second induction kept a CDAI clinical response in 75.8% on subcutaneous 360 mg at week 52.

  • ESGO 2022: Creative writing as a form of therapy

    Dr Adak Pirmorady-Sehouli talks in an interview about creative writing as a form of therapy in gynaecological oncology and how it can help in treatment.

  • Upadacitinib shows fast onset of action and high efficacy in CD

    Upadacitinib led to remission rates and endoscopic response in almost half of intensively pretreated patients with moderate-to-severe Crohn's at week 12.

  • Overall survival benefit of abiraterone in mHSPC is maintained for 7 years

    Addition of enzalutamide to AAP does not improve overall survival of metastatic hormone-sensitive prostate cancer patients, STAMPEDE trial results show.

  • Alarmingly low detection rates of pancreatic cancer

    A study revealed that pancreatic cancer was initially missed in CT or MRI scans in 7.7% of the affected patients, reducing chances of curative surgery.

  • The high price of digestive diseases

    A new Europe-wide study highlights the worrying increase in the prevalence of various digestive diseases since 2000.

  • Does a larger dose interval of adalimumab maintenance work in CD?

    Maintenance therapy with an higher dose interval of adalimumab resulted in similar persistent flare rares in Crohn's Disease patients in stable remission.

  • OS benefit in ovarian cancer patients treated with maintenance olaparib

    Addition of maintenance olaparib to bevacizumab provides clinically meaningful overall survival benefit in patients who are HRD-positive.

  • ESD: A gamechanger in colorectal lesions?

    Though widely used in Japan, in Europe its application has been on the rise in recent years: How can colorectal ESD help in gastroenterology?

  • Update: Etrasimod’s effect on immune cells in UC

    Etrasimod leads to significant reductions in T and B cell subsets and paralleled reductions in absolute lymphocyte counts, showed the ELEAVATE trials.

  • Defeating Helicobacter pylori: Mission impossible?

    H. pylori is considered the main cause of gastric cancer. If we eradicate it, other stomach-related diseases may become rarer. Are we close to achieving this?

  • Does vilobelimab reduce mortality in severe COVID-19?

    Since vilobelimab displayed an acceptable safety profile in this population, the developers aim to discuss the results with the regulatory authorities.

  • Inhaled agent under investigation for COVID-19

    Inhaled beta-1a did not meet primary endpoint in hospitalised COVID patients but may improve clinical outcomes more severe disease or risk factors cases.

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