• A physician in Antarctica, "the ultimate adventure"

    In Antarctica, thirteen people are cut off from the world for nine months. Among them, a physician with heavy duties, yet in an extraordinary adventure.

  • Is early surgery an underestimated treatment in patients with limited CD?

    Early surgery might benefit Crohn's patients, but identifying exact patient groups who will benefit from early surgery requires prospective studies.

  • Adenoma detection rates augmented by AI in colonoscopy

    Compared to conventional colonoscopy, the addition of artificial intelligence entailed significantly higher detection and lower rates of missed adenomas.

  • Advanced melanoma: Tumour-infiltrating lymphocytes outperform ipilimumab

    Second-line treatment with TIL improves PFS compared with ipilimumab in patients with advanced, non-resectable stage III–IV melanoma.

  • Mirikizumab shows sustained maintenance of symptom remission in ulcerative colitis

    Symptom control maintenance after 40 weeks was investigated in mirikizumab responders after a 12 week induction therapy.

  • Combined TYK2/JAK1 inhibition shows promise in hidradenitis suppurativa

    Brepocitinib demonstrated significant efficacy in Hidradenitis Suppurativa Clinical Response (HiSCR) and flare reduction in hidradenitis suppurativa (HS).

  • Robotics in elderly care: When the machine needs a helping hand

    Which technologies are useful for nursing home residents? And how can they be designed to respect their needs and protect their dignity?

  • H. pylori eradication protects against ulcer bleeding in aspirin users

    Significantly less ulcer bleeding was found in patients with chronic aspirin use who underwent eradication of Helicobacter pylori, according to HEAT trial results.

  • High maintenance rates for novel IL-13 inhibitor in AD

    Up to 80.6% of Phase 3 ADvocate trial responders, based on dosing interval, stayed clear or almost clear of lesions from weeks 16 to 52, according to the IGA scale.

  • Light at the end of the tunnel for children with eosinophilic oesophagitis

    In the phase 3 EoE KIDS trial, dupilumab showed remarkable efficacy in paediatric patients with eosinophilic oesophagitis.

  • IL4/IL13 blockade shows remarkable efficacy in prurigo nodularis

    A second phase 2 trial showed prurigo nodularis patients treated with dupilumab had a remarkable itch improvement from baseline to week 24.

  • Longitudinal microbiome changes hold diagnostic value

    For the first time, a study assessed longitudinal changes in microbiota during therapy with immune checkpoint inhibitors (ICIs).

  • Postponed drainage beneficial with infected necrotising pancreatitis

    Follow-up >6 months for necrotising pancreatitis infections with immediate or delayed drainage showed no influence on mortality or major complications.

  • What physicians should know about psychedelic therapy

    Drugs for mental health? That may still seem strange to some. We explain what physicians need to know about novel forms of therapy with psychedelic substances.

  • Additional clinical benefit of risankizumab in patients with delayed response

    Crohn's patients who responded only after a risankizumab second induction kept a CDAI clinical response in 75.8% on subcutaneous 360 mg at week 52.

  • ESGO 2022: Creative writing as a form of therapy

    Dr Adak Pirmorady-Sehouli talks in an interview about creative writing as a form of therapy in gynaecological oncology and how it can help in treatment.

  • Upadacitinib shows fast onset of action and high efficacy in CD

    Upadacitinib led to remission rates and endoscopic response in almost half of intensively pretreated patients with moderate-to-severe Crohn's at week 12.

  • Overall survival benefit of abiraterone in mHSPC is maintained for 7 years

    Addition of enzalutamide to AAP does not improve overall survival of metastatic hormone-sensitive prostate cancer patients, STAMPEDE trial results show.

  • Alarmingly low detection rates of pancreatic cancer

    A study revealed that pancreatic cancer was initially missed in CT or MRI scans in 7.7% of the affected patients, reducing chances of curative surgery.

  • The high price of digestive diseases

    A new Europe-wide study highlights the worrying increase in the prevalence of various digestive diseases since 2000.

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