Chronic hand eczema (CHE) is a recurrent inflammatory reaction around the hands. Often visible, it adds a psychological burden for those affected. Delgocitinib showed a good effect with a favorable side effect profile.
Biologics have significantly improved the treatment of dermatological diseases. Their use in the treatment of melanoma and atopic dermatitis was discussed during the virtual EADV Congress on 31 October 2020.
The study highlights how SARS-COV-2 manifests itself through respiratory or mental symptoms, and also through very specific neuropsychological signs such as agraphia and conduction aphasia.
Infections with SARS-CoV2 also manifest themselves on the skin. Different patterns of dermatological symptoms were presented and the underlying pathophysiology discussed at the virtual EADV Congress 2020.
BRAF and MEK inhibitors have been proving their worth for years in melanoma treatment. A number of substances are in clinical development and testing for psoriasis and other inflammatory diseases.
Prof. Stratigos covers the virtual congress' hot topics, such as microbial therapy for psoriasis, the influence of artificial intelligence, and the challenges of the COVID-19 pandemic.
An open-label study from France showed that a low-FODMAPs diet did not have any benefit over a standard diet to improve symptoms in patients with PPI-refractory gastro-oesophageal reflux disease (GERD).
A prospective population-based study from Sweden demonstrated for the first time a possible causal link between duodenal inflammation and psychological distress in a functional gut disorder.
The appearance of Bifidobacterium longum NCC2705 in duodenal aspirates was associated with a concomitant increase in serpin concentration in celiac disease or non-celiac gluten-sensitivity patients.
Most IBS patients who responded to fecal transplantation maintained this response after 1 year. Improvements in symptoms, quality of life, fecal bacterial profile, and short-chain fatty acids increased significantly.
Results from the LAUREL trial showed that despite nominally significant benefits with etrolizumab, endoscopic remission and histologic remission was not met in a cohort of TNF-naïve ulcerative colitis patients.
Filgotinib was effective and well-tolerated as maintenance treatment for patients with moderately to severely active ulcerative colitis who had achieved a clinical response to induction treatment with this drug.
Weekly dupilumab demonstrated significant and clinically meaningful improvements in histologic, symptomatic, endoscopic, and molecular aspects of eosinophilic esophagitis (EoE).
Hackers use the ransomware technique to block a computer network and demand a ransom to restore access to it. A first (indirect) death caused by such an attack occurred in a German hospital.
An analysis of an Australian tertiary health network showed a significant improvement in overall sessile serrated adenoma detection rate (SSADR) over a 4-year period.
Post-colonoscopy colorectal cancers accounted for a substantial proportion of all IBD-related colorectal cancers. However, IBD patients had a low absolute risk of post-colonoscopy colorectal cancers.
Mirikizumab demonstrated sustained efficacy at week 52 in patients with moderate-to-severe Crohn’s disease. In the maintenance period of the phase 2 SERENITY trial, few patients discontinued due to adverse events.
A Japanese study showed that the presence or absence of cholecystectomy does not affect biliary tract problems or mortality in patients ≥80 years old. Follow-up may be appropriate, without surgery.
The uroguanylin-analog plecanatide is an effective symptomatic treatment for patients with IBS-C. An early clinical response appeared to be predictive of overall response after 12 weeks.
TNF antagonists do not appear to be associated with severe COVID-19, a large, international registry to monitor outcomes of IBD patients with confirmed COVID-19 found.