Our results indicate that BRAF-mutated serrated polyps are molecularly more similar to normal colon tissue than APC- and/or CTNNB1-mutated tumors. Overall, molecular tumor profiling of individuals with polyposis contributes to understanding the genetic disease etiology.
A subtle increase in eosinophils has also been observed in other GI diseases including functional dyspepsia in the duodenum. Targeted drug therapy can markedly reduce eosinophil infiltration, although symptom response is more variable, suggesting that non–eosinophil pathways play a role in pathogenesis.
UEMR achieved a resection depth comparable to that of CEMR. Given its consistent negative horizontal margins, UEMR may become the gold standard for resecting intermediate-sized colorectal tumors.
In this randomized clinical trial in 124 patients assessing ethosuximide to improve IBS-related abdominal pain, intention-to-treat analysis showed no significant difference in responder rates between ethosuximide and placebo. Ethosuximide had limited tolerability, with higher discontinuation rates, and induced more adverse events compared with placebo.
A better understanding of the morphological assessment of ECL hyperplasia using H&E -stained sections is necessary to improve the understanding and diagnosis of ECL hyperplasia, to avoid missed diagnoses, and to facilitate subsequent clinical monitoring and treatment.
By inducing growth of the intestinal epithelium, the drug teduglutide, used for the treatment of short bowel syndrome-associated intestinal failure, could feasibly promote growth of pre-existing colonic neoplasms and incite the development of new ones.
What may seem questionable at first glance has a perfectly plausible explanation: the gut-brain axis as an important mediator between the enteric and central nervous systems.
We analyzed consecutive colorectal ESD procedures performed at our center between 2017 and 2024. SITE-PCM was used in all cases. Lesion characteristics, procedural outcomes, histopathological findings, adverse events, and follow-up data were analyzed.
Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further investigated through clinical practice evidence studies.
Inflammatory diseases have been associated with increased risk of venous thromboembolism (VTE). However, data on VTE are lacking in large population-based cohorts of microscopic colitis (MC).
This study comprehensively assesses the global, regional, and national burden of gastric cancer (GC) attributable to smoking and a high-sodium diet from 1990 to 2021, aiming to promote healthy lifestyle habits and provide scientific evidence for policy-making.
This study demonstrated that specific histological features are associated with the severity and chronicity of DILI. Importantly, an interlobular duct loss >25% seems to be an early risk factor for continued biochemical abnormalities.
Reports on the rates of surgical recurrence at the ileocolic resection site in the biologic era are limited. The surgical recurrence rates at the ileocolic resection site in Australia (2007-2023) were 4.5% (95% confidence interval, 2.8%-6.1%) and 12.8% (95% confidence interval, 8.8%-16.5%) at 5 and 10 years, respectively. Smoking was the only risk factor significantly associated.
Despite acknowledgement of the relationship between iron deficiency anemia (IDA) and Helicobacter pylori (H. pylori), consensus is lacking on clinical practice implications. This study sought to examine the association of iron deficiency and anemia with the precancerous lesion gastric intestinal metaplasia (GIM) in a cohort of patients with active H. pylori infection.
Who benefits most from fruquintinib in metastatic colorectal cancer? A subgroup analysis of the FRESCO-2 study focuses on individuals with long overall survival.
Achalasia patients have higher risk of oesophageal cancer. A new study identifies oesophageal Candida infections as a possible cancer development risk factor.
Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional endoscopy. The aim of this study was to develop and evaluate an automatic severity grading system (ASGS) for assessing the inflammatory activity of UC using pCLE.
We established population-specific spleen volume reference values using deep learning-based segmentation. The model enables objective identification of splenomegaly from routine clinical parameters, supporting its integration into artificial intelligence-assisted radiology workflows.
These results underscore the potential of fungal biomarkers in elucidating IBD pathogenesis and its associated complications, which opens up promising avenues for targeted therapeutic strategies.
In this randomized clinical trial, liraglutide provided greater weight loss at 12 months than placebo in a cohort of patients with a suboptimal response to MBS. These results suggest that combining obesity management medications with MBS affords the opportunity to increase weight loss for those with a suboptimal initial response or weight regain, potentially avoiding conversion surgery.