A watch-and-wait approach in patients with high probability of spontaneous CBDS passage could avoid unnecessary ERCP and related adverse events in these patients. Further large-scale, prospective studies are needed to validate these findings.
This narrative review summarizes the current knowledge on using intestinal ultrasound (IUS) in patients with Crohn’s disease. The benefits and challenges of using IUS in clinical trials and real-world practice are discussed.
Dysbiosis of the salivary microbiota was observed in subjects with gastroesophageal reflux symptoms (GERSs) alone, as well as in those with combined conditions such as GERS and esophagitis, or esophagitis and Barrett's esophagus.
A total of 85 524 women diagnosed with cervical cancer between 1975 and 2021 were identified, with a follow-up of 822 630 person-years. Among these women, 64 cases of anal cancer were diagnosed.
A review summarises the current state of care for older people with IBD – from treatment response and symptoms to quality of life and psychological stress.
This study provides a comprehensive human milk transcriptomic catalog and highlights that MFG could serve as a useful biomarker for milk transcriptome analysis, offering insights into the genetic factors influencing milk production.
Gut microbiomes influence intestinal inflammation, metabolic disorders, or cancer, and enable new therapies like probiotics or faecal transplants.
New therapies for liver, pancreatic and biliary tract tumours offer promising prospects. But innovation also means ensuring equitable access, quality of life and multidisciplinary care pathways.
Current guidelines advise against the routine use of AI-supported systems for detecting polyps. Why is this the case, and what is the data situation?
This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis using summary data from large-scale genome-wide association studies (GWAS).
The results displayed that sipeimine could alleviate gastric tissue damage and decrease the levels of SOD, MDA, IL-6, IFN-γ, TNF-α, and IL-1β. Sipeimine treatment also adjusted macrophage polarization and the balance of Th17/Treg cell by reducing the expression of Jak1/2, p-Jak1/2, Stat1/3, and p-Stat1/3.
Liver cirrhosis is a complex and progressive condition resulting from sustained liver injury and chronic inflammation. Characterized by extensive fibrosis, disrupted liver architecture, and impaired function, cirrhosis represents the end stage of many chronic liver diseases.
In this multicenter case-control study of 809 specimens from 480 patients in the training and validation cohorts, the 10-microRNA signature Destinex assay demonstrated robust performance for early detection of gastric cancer, achieving high area under the curve values in both the training and validation cohorts.
An international group of experts has spoken out against the routine use of AI-based detection systems in colonoscopies – but why?
Inflammatory bowel disease (IBD) is associated with various extra-intestinal manifestations. We aim to identify comorbidities in IBD and the timing of their development to provide potentially useful insight into the associations with IBD.
Medically refractory ulcerative colitis may require colectomy with ileal pouch-anal anastomosis. Complications of the J-pouch include pouchitis, occurring in 50%-80% of patients, and Crohn’s disease (CD) of the pouch, occurring in 3%-17%. Our aim was to evaluate the efficacy and safety of ustekinumab (UST) and vedolizumab (VDZ) in patients with CD of the pouch.
In the Cystic Fibrosis (CF) modulator era, focus for many has shifted from growth and survival to prevention of diet-related chronic diseases. In doing so, diet quality should be prioritised. However, factors influencing diet quality in CF have yet to be examined. This study aims to explore relationships between health-related quality of life (HRQoL), demographic and clinical characteristics, and diet quality in adults living with CF.
The prognosis of biliary tract cancer (BTC) is poor, and recurrence rates remain high even after curative resection. This study aimed to compare the efficacy and safety of capecitabine and 5-fluorouracil/leucovorin (FL) as adjuvant treatments following curative resection in patients with BTC.
While effective in ascites control, sodium restriction may compromise nutritional status, heighten sarcopenia risk, and increase mortality, highlighting the need for a more individualized dietary approach.
A simple saliva test outperforms the standard questionnaire for reflux cough with 83.6% accuracy. The pepsin test demonstrates its superiority particularly in cases of non-acid reflux.