• Adherence to infliximab treatment in patients with immune-mediated inflammatory diseases from a referral center in Brazil: a cohort study

    This ambispective cohort study included patients treated at the Professor Edgard Santos University Hospital (HUPES) referral center of our university hospital between March 2022 and February 2023. Sociodemographic, clinical, and pharmacotherapeutic data were collected from 101 patients through interviews and medical record reviews using a structured form.

  • Segatella clades adopt distinct roles within a single individual’s gut

    Within the confines of a single gut microbiome, we have isolated 63 strains from diverse lineages of Segatella. We performed comparative analyses that exposed differences in cellular morphologies, preferences in polysaccharide utilization, yield of short-chain fatty acids, and antibiotic resistance across isolates.

  • Cendakimab meets primary endpoints in eosinophilic oesophagitis

    Cendakimab outperformed placebo in patients with eosinophilic oesophagitis (EoE) across various efficacy endpoints in a phase 3 study.

  • Tradipitant improves symptoms of motion sickness

    Tradipitant successfully reduced nausea and vomiting associated with motion sickness in a clinical trial. Both low dose and high doses were well-tolerated.

  • Diagnostic accuracy of fluorescence confocal laser microscopy after EUS-TA

    Fluorescence confocal laser microscopy may allow real-time tissue diagnosis from solid pancreatic lesions, via an endoscopic ultrasound procedure.

  • Guar gum alleviates IBS-related constipation in randomised-controlled trial

    Partially hydrolysed guar gum (PHGG) appeared to be efficacious in patients with irritable bowel syndrome-associated chronic constipation.

  • An accelerated treatment approach may save lives in pancreatic walled-off necrosis

    An accelerated treatment algorithm appeared to benefit patients with large pancreatic WON in terms of length-of-stay in the hospital and major complications.

  • Is FMT a viable option to treat primary C. difficile infections?

    A study found faecal microbiota transplantation was safe and non-inferior to vancomycin in patients with primary Clostridioides difficile infections.

  • CULTIVATE: Good signal for etrasimod in Crohn’s disease

    Etrasimod was associated with favourable outcomes and tolerability in patients with moderately to severely active CD in a phase 2 trial extension.

  • Malabsorption - key concepts and clinical approaches

    Key issues were discussed at the UEG Week related to current approaches to diagnostics, treatment and practical takeaways of malabsorption syndromes.

  • Mistakes in Lower GI: insights from UEG Week 2024

    A special congres session took a critical look at common errors in the management of lower gastrointestinal conditions, providing insights for clinical practice.

  • From guidelines to clinical practice: HPB

    Hepatobiliary and disease guidelines and updates were discussed during a session on prancreas-related cancer, exocrine insufficiency, cysts, and NASH.

  • Effect of roasted purple laver (nori) on vitamin B12 nutritional status of vegetarians: a dose-response trial

    The study design is an open-label, parallel, dose-response randomized controlled trial. Thirty vegetarians were assigned to control (no nori), low-dose (5 g nori, aiming to provide 2.4 µg vitamin B12 per day), or high-dose (8 g nori, aiming to provide 4 µg vitamin B12 per day) groups.

  • Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer

    We identify functional changes to microbial pathways including dysregulated nucleic acid, amino acid, and carbohydrate metabolism, as well as disruption of intestinal barrier function. Our findings suggest that clock disruption impinges on microbiota composition and intestinal permeability that may contribute to CRC pathogenesis.

  • Non-alcoholic fatty liver disease: The importance of physical activity and nutrition education—A randomized controlled study

    NE and PA recommendations led to improvements in liver-related biochemical parameters and significant reductions in anthropometric measurements among individuals with NAFLD.

  • Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease

    This was a retrospective cohort study of patients with no PD history undergoing upper endoscopy with biopsy between January 2000 and December 2005, with final follow-up assessments completed July 31, 2023. The study was conducted within the Mass General Brigham system, a multicenter network in the greater Boston, Massachusetts, area.

  • The Public's Intended Uptake of Hypothetical Esophageal Adenocarcinoma Screening Scenarios: A Nationwide Survey

    Screening for early esophageal adenocarcinoma (EAC) may potentially reduce EAC-related mortality and morbidity. This study aimed to examine the Dutch population's intended uptake of 3 hypothetical EAC screening test scenarios and preferences for potential future organization.

  • Lead poisoning as a differential diagnosis in pediatric patients with chronic abdominal pain

    The case–control study was conducted on 190 pediatrics who presented to the Children's Medical Center Hospital clinics, Tehran between April 2021- 2023.

  • Analysis of antimicrobial resistance and genetic diversity of Acinetobacter baumannii in a tertiary care hospital in Haikou City

    We conducted a retrospective analysis of 513 A. baumannii isolates collected from a tertiary care hospital in Haikou between January 2018 and December 2020, focusing on their antimicrobial resistance patterns.

  • Soft drinks increase liver cancer and liver-related mortality

    Sugary drinks cause weight gain and heart damage. Regarding liver damage, US researchers argue it may depend on the sweeteners.

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