Colorectal cancer (CRC) incidence in those under age 50 is increasing and minority populations are known to have worse CRC survival outcomes. Therefore, we evaluated 5-year CRC-specific survival by race and ethnicity among medically insured patients with early-onset CRC (EOCRC).
We conducted a prospective, single-center study including IBD patients and healthy controls scheduled for colonoscopy with uniform bowel preparation. Fecal samples were collected at 7 time points prior, during, and until 3 months after the intervention.
Antibiotics can be an alternative to surgery in acute appendicitis and can result in approximately two-thirds of patients not requiring appendectomy in the first year.
We assessed outpatients undergoing upper gastrointestinal endoscopy for various symptoms, obtaining biopsies from endoscopically suspected esophageal metaplasia (ESEM) at least 1 cm above the gastroesophageal junction.
In this cross-sectional study that included 64 445 gastrointestinal cases among 2 Bangladesh refugee camps (33 280 gastroenteritis cases in Kutupalong and 31 165 gastroenteritis cases in Nayapara), the risk of gastroenteritis generally increased in colder temperatures.
A first large phase III study investigated whether aspirin can reduce recurrence risk after completed standard therapy, with unexpected results.
In this study, we developed a reproducible and robust culture method to generate a human intestinal organoid-derived monolayer model that can be applied to study drug absorption through a step-by-step approach.
Nutrition is believed to impact Crohn's disease. Yeast in particular and the body's own immune response to it could play an important pathophysiological role.
Small bowel (SB) video capsule endoscopy (VCE) is an established diagnostic tool for the investigation of SB pathologies. Despite clinical studies and a few meta-analyses, an area of continuing controversy is the role of pre-procedural bowel preparation.
A systematic search was carried out in PubMed, Web of Science, Scopus, and EMBASE as well as some domestic databases including SID, Magiran, IranDoc, IranMedex from inception to the end of 2023.
A 39-year-old man presents to the emergency department with acute abdominal pain, anaemia, and diarrhea: what diagnosis lies behind this condition?
We analysed nationally representative primary care records from Clinical Practice Research Datalink (CPRD) GOLD and replicated in CPRD Aurum. We calculated incidence rates, and short- and long-term survival stratified by age, sex, and diagnosis year.
Despite the lack of viral dissemination and pathological traits in the stomach, SARS-CoV-2 infection caused dramatic changes to the molecular profile and some immune subsets in this organ. Notably, the gene sets related to metaplasia and gastric cancer were significantly enriched after viral infection.
The colitis-induced changes in the abundance of stromal cell subsets differed considerably between the 3 colitis mouse models. Interestingly, treatment with IBD medication affected specific stromal subsets in a therapy and model-specific manner.
In this cluster randomized clinical trial of 5614 Medicaid enrollees at 28 rural clinics in Oregon, a mailed FIT outreach and patient navigation program led to a significant 7.3–percentage point increase in colorectal cancer (CRC) screening over usual care.
A 55-year-old woman suffers paraplegia, anemia, and recurrent infections. What is the underlying diagnosis?
Lugol’s chromoendoscopy (LCE)–based detection of esophageal squamous cell neoplasia (ESCN) is limited by low specificity. High-resolution microendoscopy (HRME) was shown to improve specificity and reduce unnecessary biopsies when used by academic endoscopists. In this international randomized controlled trial, we determined the clinical impact, efficiency, and performance of HRME in true global health contexts with a range of providers.
Using a multi-omics approach, this study investigated Clostridioides difficile infection (CDI) as a direct contributor to hepatic dysmetabolism. Fifty-four C57BL/6 mice were divided into Control, Antibiotic control (Abx), and C. difficile-infected (C. diff) groups.
Celiac disease is associated with higher osteoporosis risk. A recent study suggests that muscle mass, BMI and bone health may be linked in those affected.
We conducted a comprehensive literature search in databases from inception to July 2024. Subgroup analyses and meta-regression were performed to determine factors associated with HBsAg seroclearance, including ethnicity, HBV genotype, NA therapy duration, end-of-treatment (EOT) qHBsAg levels, HBeAg status, cirrhosis status, and follow-up duration.