• For ulcerative colitis: compensate for selenium deficiency!

    Selenium deficiency is a common find in inflammatory bowel diseases. Recent studies emphasise that there is a benefit in selenium intake for these patients.

  • Severe Cholestasis Predicts Recurrent Primary Sclerosing Cholangitis Following Liver Transplantation

    Primary sclerosing cholangitis (PSC) may reoccur following liver transplantation (LT), and the diagnosis established once imaging studies demonstrate the diagnostic cholangiographic appearance. To evaluate whether the development of recurrent PSC (rPSC) is associated with cholestasis soon after LT, we studied whether changes in hepatic biochemistry within the first 12 months were linked with the development of rPSC and graft loss.

  • Review Article: Albumin and Its Role in Inflammatory Bowel Disease: The Old, the New, and the Future

    Circulating albumin concentrations are frequently measured in clinical practice. This review explores biochemical properties and physiological roles of albumin, its place in nutritional assessment, current understanding of perturbed circulating concentrations, and role in clinical management, with special focus on patients with inflammatory bowel disease (IBD).

  • Resting-State Functional Connectivity of the Cerebellum Differs Between Persons With Inflammatory Bowel Disease and Healthy Controls in Relation to Executive Function

    Persons with inflammatory bowel disease exhibit a weaker relationship between executive function and functional connectivity of cerebellar regions (VIIa Crus I and VIIa Crus II) to cortical areas involved in visual processing compared to healthy counterparts with comparable performance.

  • Automatic Quality Control System and Adenoma Detection Rates During Routine Colonoscopy

    In this randomized clinical trial that included 1254 adults, the AQCS-assisted group achieved a significantly higher adenoma detection rate vs the standard colonoscopy group (32.7% vs 22.6%).

  • Age-period-cohort analysis of gallbladder and biliary diseases epidemiological trends from 1990 to 2021 and forecasts for 2035: a systematic analysis from the global burden of disease study 2021

    GABD continue to pose a significant global public health challenge, particularly affecting women and the elderly population. Consequently, the implementation of effective interventions to mitigate the GABD burden is of paramount importance.

  • Neighborhood Socioeconomic Deprivation and 30-Day Outcomes After Admission for Common Gastrointestinal Conditions: A Large Nationwide Study

    We analyzed a nationwide sample of United States Medicare beneficiaries hospitalized from 2017-2019 for common gastrointestinal diseases, grouped by Diagnosis Related Groups (DRGs).

  • Impact of Prior Biologic Exposure on Ozanimod Efficacy and Safety in the Phase 3 True North Clinical Trial

    Patients with ulcerative colitis (UC) and prior biologic failure may have reduced or delayed efficacy with subsequent advanced therapies. This analysis evaluated the efficacy and safety of ozanimod during the True North (TN) study and its open-label extension (OLE) in biologic-exposed patients with UC.

  • Discussion of age limits for bowel cancer screening

    A recent cost-effectiveness analysis addressed the question of the appropriate age for the start and end of screening colonoscopies.

  • Daily sodium intake and constipation in US adult males: an uncommon negative association revealed by national health and nutrition examination survey data from the United States (2005–2010)

    This study demonstrates a negative association between daily sodium intake and constipation risk among adult males, suggesting that sodium intake might influence intestinal function.

  • A hybrid framework for colorectal cancer detection and U-Net segmentation using polynetDWTCADx

    “PolynetDWTCADx” is a sophisticated hybrid model that was developed to identify and distinguish colorectal cancer. In this study, the CKHK-22 dataset, comprising 24 classes, served as the introduction.

  • Pregnancy With a Stoma is Feasible, Though Associated With Manageable Complications

    Pregnancy with a stoma is feasible, though manageable complications often occur. Counseling before pregnancy and close monitoring of symptoms during pregnancy and postpartum are essential for women with IBD and a stoma.

  • Method to define recommended portion sizes for consumer guidance

    This standardized approach provides clear and consistent portion recommendations that, if adopted, could help consumers make informed choices about appropriate portions.

  • Innovations and perspectives in liver transplantation

    Liver transplantation is a rapidly developing field. Advanced technologies, like AI, will improve access, outcomes, and offer more personalized care.

  • Optimal endoscopy timing in elderly patients presenting with acute non-variceal upper gastrointestinal bleeding

    Optimal endoscopy timing becomes even more complicated when taking into account the higher probability of mortality in the elderly presenting with UGIB. The current study aimed to evaluate the optimal endoscopy time in elderly patients based on clinical outcomes.

  • Tamuzimod delivers promising long-term data in ulcerative colitis

    Tamuzimod improved clinical, endoscopic, and histologic outcomes compared with placebo in moderately to severely active UC at week 52.

  • Upadacitinib associated with normalisation of HRQoL in UC

    Upadacitinib induction and maintenance therapy were associated with higher rates of normalisation of health-related quality-of-life (HRQoL) than placebo.

  • TL1A inhibitor tulisokibart shows potential in ulcerative colitis

    Tulisokibart displayed durable improvements in clinical and endoscopic outcomes in patients with moderately to severely active ulcerative colitis.

  • New insights into perianal fistulising CD pathogenesis may lead to new therapeutics

    Perianal fistulising Crohn’s disease was associated with increased IFN-γ expression and response in fistula tracts and luminal mucosa.

  • Exploring zibotentan plus dapagliflozin for cirrhosis

    Data from the cirrhosis subpopulation in the ZENITH-CKD trial suggest that the zibotentan and dapagliflozin combination may benefit liver health.

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