• Interview: Prof. Rimassa on rare tumours, real needs, and a clinical systemic overview

    New therapies for liver, pancreatic and biliary tract tumours offer promising prospects. But innovation also means ensuring equitable access, quality of life and multidisciplinary care pathways.

  • AI-supported detection systems in colonoscopies: Help or hype?

    Current guidelines advise against the routine use of AI-supported systems for detecting polyps. Why is this the case, and what is the data situation?

  • Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis

    This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis using summary data from large-scale genome-wide association studies (GWAS).

  • Sipeimine reduces ethanol-induced gastric ulcer in mice by suppressing Jak-Stat activation and restoring gut microbiota balance

    The results displayed that sipeimine could alleviate gastric tissue damage and decrease the levels of SOD, MDA, IL-6, IFN-γ, TNF-α, and IL-1β. Sipeimine treatment also adjusted macrophage polarization and the balance of Th17/Treg cell by reducing the expression of Jak1/2, p-Jak1/2, Stat1/3, and p-Stat1/3.

  • Unraveling Liver Cirrhosis: Bridging Pathophysiology to Innovative Therapeutics

    Liver cirrhosis is a complex and progressive condition resulting from sustained liver injury and chronic inflammation. Characterized by extensive fibrosis, disrupted liver architecture, and impaired function, cirrhosis represents the end stage of many chronic liver diseases.

  • Exosomal Liquid Biopsy for the Early Detection of Gastric Cancer: The DESTINEX Multicenter Study

    In this multicenter case-control study of 809 specimens from 480 patients in the training and validation cohorts, the 10-microRNA signature Destinex assay demonstrated robust performance for early detection of gastric cancer, achieving high area under the curve values in both the training and validation cohorts.

  • New guideline: AI is not routinely recommended for colonoscopies

    An international group of experts has spoken out against the routine use of AI-based detection systems in colonoscopies – but why?

  • Inflammatory bowel disease and risk of more than 1500 comorbidities: A disease-wide pre- and post-diagnostic phenomic association study

    Inflammatory bowel disease (IBD) is associated with various extra-intestinal manifestations. We aim to identify comorbidities in IBD and the timing of their development to provide potentially useful insight into the associations with IBD.

  • Efficacy and Safety of Ustekinumab and Vedolizumab for Crohn’s Disease of the Pouch

    Medically refractory ulcerative colitis may require colectomy with ileal pouch-anal anastomosis. Complications of the J-pouch include pouchitis, occurring in 50%-80% of patients, and Crohn’s disease (CD) of the pouch, occurring in 3%-17%. Our aim was to evaluate the efficacy and safety of ustekinumab (UST) and vedolizumab (VDZ) in patients with CD of the pouch.

  • Interrelationships between diet quality and health-related quality of life in Irish adults living with cystic fibrosis

    In the Cystic Fibrosis (CF) modulator era, focus for many has shifted from growth and survival to prevention of diet-related chronic diseases. In doing so, diet quality should be prioritised. However, factors influencing diet quality in CF have yet to be examined. This study aims to explore relationships between health-related quality of life (HRQoL), demographic and clinical characteristics, and diet quality in adults living with CF.

  • Comparison of 5-Fluorouracil/Leucovorin and Capecitabine as Adjuvant Therapies in Biliary Tract Cancer

    The prognosis of biliary tract cancer (BTC) is poor, and recurrence rates remain high even after curative resection. This study aimed to compare the efficacy and safety of capecitabine and 5-fluorouracil/leucovorin (FL) as adjuvant treatments following curative resection in patients with BTC.

  • Impacts of salt restriction on nutritional status, sarcopenia, and mortality of cirrhotic patients with ascites

    While effective in ascites control, sodium restriction may compromise nutritional status, heighten sarcopenia risk, and increase mortality, highlighting the need for a more individualized dietary approach.

  • Salivary pepsin: a marker for reflux cough

    A simple saliva test outperforms the standard questionnaire for reflux cough with 83.6% accuracy. The pepsin test demonstrates its superiority particularly in cases of non-acid reflux.

  • The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations

    Here, we develop a reinforcement learning-based AI Clinician system to personalise treatment selection and evaluate its ability to improve eradication success compared to clinician-prescribed therapies.

  • Feasibility and Safety of Small Bowel Capsule Endoscopy in Very Early-Onset Inflammatory Bowel Disease: A Multi-Institutional Study

    Small bowel capsule endoscopy is a valuable modality for evaluating small intestinal lesions in children with inflammatory bowel disease. However, its application for very early-onset inflammatory bowel disease remains insufficiently documented.

  • Mediterranean diet score linked to cognitive functioning in Czech women: a cross-sectional population-based study

    The evidence suggests that adherence to the Mediterranean diet (MD) may be beneficial in preventing cognitive decline. We aimed to explore this association in a Central European population.

  • ACG Clinical Guideline Update: Preventive Care in Inflammatory Bowel Disease

    Patients with inflammatory bowel disease (IBD) often consider their gastroenterologist to be the primary provider of care. To improve the care delivered to patients with IBD, health maintenance issues need to be addressed by the gastroenterology team.

  • Oral Vancomycin for Prevention of Recurrent Clostridioides difficile Infection

    In this randomized clinical trial of 81 participants who had completed treatment for a CDI and were taking systemic antibiotics for a non-CDI indication, recurrent CDI occurred in 43.6% of participants in the oral vancomycin group vs 57.1% in the placebo group at 8 weeks. However, the study was underpowered and this difference did not reach statistical significance.

  • The rising burden of gastrointestinal cancers

    A group of experts from ESMO GI 2025 highlight critical trends and new therapeutic strategies to address the global increase in gastrointestinal cancers.

  • Association between gastrointestinal symptoms and insomnia among healthcare workers: a cross-sectional study

    Although research has established that stress and shift work are independent risk factors for gastrointestinal discomfort and insomnia, the direct link between these two conditions in healthcare workers remains insufficiently explored.

  • 1 |
  • 2 |
  • 3 |
  • 4 |
  • 5 |
  • 6 |