Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional endoscopy. The aim of this study was to develop and evaluate an automatic severity grading system (ASGS) for assessing the inflammatory activity of UC using pCLE.
We established population-specific spleen volume reference values using deep learning-based segmentation. The model enables objective identification of splenomegaly from routine clinical parameters, supporting its integration into artificial intelligence-assisted radiology workflows.
These results underscore the potential of fungal biomarkers in elucidating IBD pathogenesis and its associated complications, which opens up promising avenues for targeted therapeutic strategies.
In this randomized clinical trial, liraglutide provided greater weight loss at 12 months than placebo in a cohort of patients with a suboptimal response to MBS. These results suggest that combining obesity management medications with MBS affords the opportunity to increase weight loss for those with a suboptimal initial response or weight regain, potentially avoiding conversion surgery.
This study revealed the critical value of biomarkers related to ferroptosis serving as novel predictive biomarkers for patients with LAGC receiving NAC.
These findings showed that OOACs offer more physiologically relevant environments, promote deeper cellular differentiation and increased cellular tractability when seeded as ASCs rather than classical organoid aggregates.
GI endoscopy, CT and MRI are indispensable in IBD care but carry considerable environmental costs. The broader adoption of IUS offers a clinically effective, low-carbon alternative that can contribute to more sustainable IBD management, aligning with planetary health goals.
A pilot study shows significant differences in the gut microbiome between anxious and non-anxious individuals.
News about the skin-gut-brain axis: Innovative findings on disease mechanisms promise advances in diagnosis and therapy.
These findings suggest protein intake does not benefit cognitive function in older adults. Negative associations may relate to protein food sources.
In patients with HBV-related cirrhosis, the aspirin-treated group showed a significantly lower risk of HCC than the untreated group, whereas the risk of GI bleeding was significantly higher in the aspirin-treated group.
Randomized controlled trials of glutamine in the prevention of chemotherapy-associated diarrhea of colorectal cancer were retrieved from the Cochrane Library, Pubmed, EMBASE, CNKI, and Wanfang by computer up to August 1, 2024.
In this study, we examined whether sociodemographic details were associated with differences in LLM-generated recommendations for gastroenterology presentations.
The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021.
In a prospective 12-week intervention trial, we evaluated the effects of six different plant-based fermented pickles (~ 50 g/day) on clinical, inflammatory, and gut microbiota parameters in a cohort of women (n = 230) in a rural setting with a high prevalence of undernutrition.
The phase 3 ESSENCE trial, published in NEJM, reports that once-weekly semaglutide 2.4 mg achieves significant histologic improvements in patients with MASH and stage F2–F3 fibrosis.
Very-early-onset inflammatory bowel disease (VEO-IBD) is a form of IBD that manifests in infants and young children, with a significant proportion of them carrying interleukin 10 receptor alpha (IL-10RA) mutations.
Gastrointestinal tract cancer is increasing at an unprecedented rate among younger adults worldwide, with colorectal cancer in 15- to 19-year-olds rising by 333%, for example.
Despite the pathophysiology caused by acid-GER events, human milk properties may provide better adaptation and modulation of neurosensory and neuromotor responses upon esophageal provocation.
This study highlighted the role of the GCSI in assessing and monitoring gastroparesis, particularly in resource-limited settings. Diabetic GP differs in clinical presentation and management from other types of GP.