• Association between gastrointestinal symptoms and insomnia among healthcare workers: a cross-sectional study

    Although research has established that stress and shift work are independent risk factors for gastrointestinal discomfort and insomnia, the direct link between these two conditions in healthcare workers remains insufficiently explored.

  • “Insert-Coin”: A Prospective Study of Coin Ingestion in Children of Southern Italy

    Coins are the most commonly ingested foreign bodies. When they get stuck in the distal esophagus, there is no general agreement about the timing of their removal because some of them may spontaneously migrate into the stomach, no longer requiring removal. We aimed at evaluating the gastric spontaneous passage of esophageal-retained coins, as well as complications.

  • The Association of Inflammatory Bowel Disease and Eosinophilic Esophagitis: A Systematic Review and Meta-analysis

    The association between inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE) remains unclear. We aimed to perform a systematic review and meta-analysis on the association between EoE, IBD, and other immune-mediated inflammatory diseases.

  • Accuracy of Artificial Intelligence for Gatekeeping in Referrals to Specialized Care

    In this diagnostic study of an AI model for gatekeeping that was developed, tested, and validated sequentially, the model differentiated between referrals that warranted immediate authorization and additional information with moderate accuracy and outperformed human gatekeepers by nearly 20%, primarily due to increased specificity.

  • Trends in incidence and mortality of early-onset gastrointestinal cancers: a comprehensive study

    Early-Onset Gastrointestinal Cancers concerns tumors in people under 50. Accumulating evidence suggests a significant increase in the burden of colorectal cancer in young adults. We investigated the global burden and spatiotemporal trends of the 6 major gastrointestinal (GI) cancers.

  • Efficacy and safety of Saccharomyces boulardii as adjunct therapy with Vancomycin in treating Clostridioides difficile infection: A randomized controlled trial

    Clostridioides difficile infection (CDI) is a significant cause of hospital-acquired diarrhea, leading to high morbidity, recurrence, and healthcare costs. Probiotics like Saccharomyces boulardii show potential as an adjunct therapy to standard CDI treatment, but further trials are needed to confirm their efficacy.

  • Ascites without cirrhosis: finding differential diagnoses and treating correctly

    Ascites is often equated with cirrhosis of the liver, but the causes can be much more diverse – ranging from malignant diseases and infections to rare syndromes.

  • Differences in Clinical Characteristics Between Missed and Detected Laryngopharyngeal Cancers

    Laryngopharyngeal cancers are often overlooked during endoscopy because of their anatomical complexity and the gag reflex. However, the characteristics of these cancers remain poorly understood.

  • Worldwide increase in early-onset colorectal cancer: New data and clinical implications

    In over half of countries studied, incidence is increasing among young adults, often in contrast to stable or declining rates among older patients.

  • A New Drying Method of Thermolabile Flexible Endoscope Channels by Laminar and Turbulent Airflow: A Prospective, Randomized-Controlled, Single-Center, Proof-of-Concept Trial

    The aim of this study was to compare the drying cycle of a standard endoscope washer-disinfector (EWD) (standard drying method [SD]) with a shortened mandatory drying by the EWD followed by a special drying device using laminar and turbulent air flow (novel drying method [ND]).

  • Diet-induced inflammation is associated with fatty pancreas in patients with common bile duct stones

    Inflammation has been proven to be associated with chronic diseases. We hypothesized that higher diet-induced inflammation is associated with increased risk of fatty pancreas (FP).

  • Global burden of colon and rectal cancer and attributable risk factors in 204 countries and territories from 1990 to 2021

    Using updated data from the Global Burden of Disease (GBD) 2021 study, this research explores the national-level spatial distribution of CRC burdens linked to key risk factors and analyzes temporal trends in their contributions.

  • Early-Onset Colorectal Cancer Survival by Race and Ethnicity in a Large Community-Based Insured Population

    Colorectal cancer (CRC) incidence in those under age 50 is increasing and minority populations are known to have worse CRC survival outcomes. Therefore, we evaluated 5-year CRC-specific survival by race and ethnicity among medically insured patients with early-onset CRC (EOCRC).

  • The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study

    We conducted a prospective, single-center study including IBD patients and healthy controls scheduled for colonoscopy with uniform bowel preparation. Fecal samples were collected at 7 time points prior, during, and until 3 months after the intervention.

  • Appendicitis: Can we manage it without surgery?

    Antibiotics can be an alternative to surgery in acute appendicitis and can result in approximately two-thirds of patients not requiring appendectomy in the first year.

  • Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study

    We assessed outpatients undergoing upper gastrointestinal endoscopy for various symptoms, obtaining biopsies from endoscopically suspected esophageal metaplasia (ESEM) at least 1 cm above the gastroesophageal junction.

  • Air Temperature and Gastroenteritis Among Rohingya Populations in Bangladesh Refugee Camps

    In this cross-sectional study that included 64 445 gastrointestinal cases among 2 Bangladesh refugee camps (33 280 gastroenteritis cases in Kutupalong and 31 165 gastroenteritis cases in Nayapara), the risk of gastroenteritis generally increased in colder temperatures.

  • Aspirin as a possible therapy for the prevention of colon cancer recurrences

    A first large phase III study investigated whether aspirin can reduce recurrence risk after completed standard therapy, with unexpected results.

  • Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption

    In this study, we developed a reproducible and robust culture method to generate a human intestinal organoid-derived monolayer model that can be applied to study drug absorption through a step-by-step approach.

  • Yeast: a possible antigen in Crohn's disease?

    Nutrition is believed to impact Crohn's disease. Yeast in particular and the body's own immune response to it could play an important pathophysiological role.

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