We analyzed consecutive colorectal ESD procedures performed at our center between 2017 and 2024. SITE-PCM was used in all cases. Lesion characteristics, procedural outcomes, histopathological findings, adverse events, and follow-up data were analyzed.
Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further investigated through clinical practice evidence studies.
Inflammatory diseases have been associated with increased risk of venous thromboembolism (VTE). However, data on VTE are lacking in large population-based cohorts of microscopic colitis (MC).
This study comprehensively assesses the global, regional, and national burden of gastric cancer (GC) attributable to smoking and a high-sodium diet from 1990 to 2021, aiming to promote healthy lifestyle habits and provide scientific evidence for policy-making.
This study demonstrated that specific histological features are associated with the severity and chronicity of DILI. Importantly, an interlobular duct loss >25% seems to be an early risk factor for continued biochemical abnormalities.
Reports on the rates of surgical recurrence at the ileocolic resection site in the biologic era are limited. The surgical recurrence rates at the ileocolic resection site in Australia (2007-2023) were 4.5% (95% confidence interval, 2.8%-6.1%) and 12.8% (95% confidence interval, 8.8%-16.5%) at 5 and 10 years, respectively. Smoking was the only risk factor significantly associated.
Despite acknowledgement of the relationship between iron deficiency anemia (IDA) and Helicobacter pylori (H. pylori), consensus is lacking on clinical practice implications. This study sought to examine the association of iron deficiency and anemia with the precancerous lesion gastric intestinal metaplasia (GIM) in a cohort of patients with active H. pylori infection.
Who benefits most from fruquintinib in metastatic colorectal cancer? A subgroup analysis of the FRESCO-2 study focuses on individuals with long overall survival.
Achalasia patients have higher risk of oesophageal cancer. A new study identifies oesophageal Candida infections as a possible cancer development risk factor.
Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional endoscopy. The aim of this study was to develop and evaluate an automatic severity grading system (ASGS) for assessing the inflammatory activity of UC using pCLE.
We established population-specific spleen volume reference values using deep learning-based segmentation. The model enables objective identification of splenomegaly from routine clinical parameters, supporting its integration into artificial intelligence-assisted radiology workflows.
These results underscore the potential of fungal biomarkers in elucidating IBD pathogenesis and its associated complications, which opens up promising avenues for targeted therapeutic strategies.
In this randomized clinical trial, liraglutide provided greater weight loss at 12 months than placebo in a cohort of patients with a suboptimal response to MBS. These results suggest that combining obesity management medications with MBS affords the opportunity to increase weight loss for those with a suboptimal initial response or weight regain, potentially avoiding conversion surgery.
This study revealed the critical value of biomarkers related to ferroptosis serving as novel predictive biomarkers for patients with LAGC receiving NAC.
These findings showed that OOACs offer more physiologically relevant environments, promote deeper cellular differentiation and increased cellular tractability when seeded as ASCs rather than classical organoid aggregates.
GI endoscopy, CT and MRI are indispensable in IBD care but carry considerable environmental costs. The broader adoption of IUS offers a clinically effective, low-carbon alternative that can contribute to more sustainable IBD management, aligning with planetary health goals.
A pilot study shows significant differences in the gut microbiome between anxious and non-anxious individuals.
News about the skin-gut-brain axis: Innovative findings on disease mechanisms promise advances in diagnosis and therapy.
These findings suggest protein intake does not benefit cognitive function in older adults. Negative associations may relate to protein food sources.
In patients with HBV-related cirrhosis, the aspirin-treated group showed a significantly lower risk of HCC than the untreated group, whereas the risk of GI bleeding was significantly higher in the aspirin-treated group.