Treatment with semaglutide can lead to weight loss in obese patients – but according to US data, it significantly increases the risk of gastroparesis.
Collectively, these findings suggest that Aβ promotes gut symptoms through alteration of ENS connectivity and butyrate counteracts these impairments with an amelioration of neuroinflammation and memory function in AD model.
GIB in patients with CV disease is independently associated with subsequent morbidity and mortality. Patterns in antithrombotic resumption were associated with outcomes. Further research into optimal antithrombotic management following GIB is essential.
This review summarizes evidence on epidemiology, diagnostic workup, and endoscopic ultrasound (EUS)–guided management of PanNETs, encompassing diagnostic evaluation, tissue acquisition, and therapeutic interventions.
This retrospective study included 380 hospitalized cirrhotic patients complicated by PVT, categorized into bleeding and non-bleeding groups based on history of gastrointestinal bleeding.
Mirikizumab provided sustained symptomatic, clinical, endoscopic, and histologic benefits over 4 years in responding patients with moderately-to-severely active UC, including those with prior biologic failure.
A study saw less frequent severe liver complications in MASLD patients treated with SGLT-2 inhibitors, compared to glitazones treatments, but not less than GLP-1 receptor agonists treatments.
Prior cancer was independently associated with poorer overall and cancer-specific survival and with prior stomach, head and neck, or lung cancers; the negative association with survival was also found when the prior cancer occurred more than 5 years before ESCC diagnosis.
Patients with CIPO underwent genomic profiling, including NGS panel, long-range PCR, whole-exome, and whole-genome sequencing. Centralized histological analysis of full-thickness bowel biopsies and resections was integrated with genomic data to assess their combined impact on disease outcomes.
New data shows that the widely used sweetener sucralose can impair the response to PD-1-based immunotherapies in tumor patients, due to triggered changes in the gut microbiome.
A systematic review examines the question of whether targeted respiratory muscle training can influence the anti-reflux barrier and alleviate reflux symptoms.
In this exploratory study, dietary inflammatory potential was associated with attention and processing speed at the cognitive domain level in children. These findings suggest that diet-related inflammation may be linked to specific aspects of cognitive performance in children; however, future studies with larger samples using comprehensive cognitive assessments are warranted.
In MASLD patients, higher MD adherence was associated with lower risk of significant liver fibrosis. Our findings support the recommendation of the MD as a crucial lifestyle intervention to lower the risk of liver fibrosis in this population.
Morphine causes lasting gut dysbiosis and liver inflammation, indicating disruption of the gut-liver axis in opioid dependence. These results emphasize morphine’s impact on gut microbiota and liver health, suggesting significant long-term effects of opioid use.
In this comparative effectiveness research study of 12 245 patients with CD, treated with tumor necrosis factor-α antagonists, vedolizumab, ustekinumab, risankizumab, or upadacitinib and followed up over a mean 27 months, no clinically meaningful differences in the risk of key safety events, including serious infections, venous thromboembolism, and major adverse cardiovascular events, were found.
Endoscopic spray application of hMPs demonstrated strong adhesion to gastric ulcers and was associated with the absence of delayed bleeding in this short-term experimental model. These findings suggest that hMPs may represent a promising strategy for reducing the risk of delayed bleeding after gastrointestinal endoscopic surgery.
Taken together, the culturing of patient biopsies into ALI colonoid monolayers provides a powerful model to assess human colonic mucosal development, healing, homeostasis, and mucus barrier function, revealing that UC-derived colonoid monolayers display a range of developmental and functional defects that persist in the absence of inflammation.
The study included 17 232 cases of gastric (non-cardia) adenocarcinoma and 172 297 controls. Long term proton pump inhibitor use occurred in 1766 (10.2%) cases and 16 312 (9.5%) controls. No association was found between long term proton pump inhibitor use and gastric adenocarcinoma (adjusted odds 1.01, 95% confidence interval 0.96 to 1.07).
In a European case series involving 12 children with acute hepatitis of unknown cause, pronounced CD8 T-cell infiltrates were found in the liver, along with SARS-CoV-2 proteins.
Routine mental health screening and COMPASS-IBD were successfully implemented in an outpatient IBD service, but support from trainee psychologists and the research team was required. This new integrated pathway can identify and treat psychological distress in IBD with minimal service resource.