Through integrated multi-omic analysis, we detected covarying microbial and metabolic features, such as Bilophila wadsworthia and bile acids, specific to diverticulitis. Additionally, we observed that microbial composition modulated the protective association between a prudent fiber-rich diet and diverticulitis.
In this cohort study of 1313 patients, only 42.3% of cases of HCC were detected by screening. Detection by screening was associated with improved early-stage detection and survival, which persisted after adjusting for lead-time and length-time biases.
Proton pump inhibitors (PPIs) are one of the most commonly prescribed classes of drugs, but an estimated 25-70% of PPI users may not have an appropriate indication, depending on the clinical setting. For such patients, PPIs cause unnecessary healthcare spending and pill burden.
Children with Alpha-1-antitrypsin deficiency (AATD) exhibit a wide range of liver disease outcomes from portal hypertension and transplant, to asymptomatic without fibrosis. Individual outcomes cannot be predicted. High circulating Z polymer levels and high GGT early in life are associated with future CEPH in AATD, and use of predictive cutoffs may assist in future clinical trial design.
Variation in outcomes and costs cannot be used to differentiate between hospitals for quality of care. Future quality improvement initiatives should look at differences in structure and process measures of care and implement patient-level interventions to improve quality of IBD care.
Imaging-based diagnosis of sarcopenia via L3-SMI is associated with a low TFS in patients with PSC and may provide additional benefits as a prognostic factor in patient selection for liver transplantation.
Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
Researchers used a new statistical method to identify the genetic basis of the link between red and processed meat intake and colorectal cancer risk.
Do patients with non-erosive gastro-oesophageal reflux need regular follow-up endoscopies to prevent cancer? A long-term cohort study argues against this.
A recent study argues for a treatable cause behind dementia symptoms: hepatic encephalopathy, in the context of unrecognised liver cirrhosis.
We observed that night eating syndrome was very common in esports players and that these individuals were at risk in terms of food addiction. Since esports has a more sedentary structure than traditional sports, we suggest that esports players should be evaluated in terms of their unhealthy eating behaviors and risk of eating disorders.
LP reproducibility is feasible under water-perfused HRM, and comparative studies could bring similarity to dataset expansion. Novel 3D parameters need further studies with healthy and larger data to be validated and for disease comparisons.
The results demonstrate that IMR-CNN exhibits superior accuracy compared to MR-CNN in both EGC detection and lesion segmentation. To enhance the robustness of the findings, a rigorous fivefold cross-validation was performed on a self-built dataset, verifying the reliability of the models.
In this cohort study of 1293 patients, the anti–H pylori treatment group had a significant survival advantage compared with the non–anti–H pylori treatment group in terms of overall survival and disease-free survival. After propensity score matching, the survival advantage for both overall and disease-free survival remained.
This study provides insights into medication patterns in pregnant IBD patients and suggests no increased risk of MCMs associated with first-trimester IBD medication use.
Antibiotic resistance is one of the main factors that determine the efficacy of treatments to eradicate Helicobacter pylori infection. Our aim was to evaluate the effectiveness of first-line and rescue treatments against H. pylori in Europe according to antibiotics resistance.
Over 9,000 heart disease deaths could be avoided by 2041 in England if all gastronomy establishments displayed calorie disclaimers on their menus.
Bowel urgency and bowel urgency-related accidents are accompanied by several bothersome symptoms and considerably impact patients’ quality of life, highlighting the need to develop a patient-reported outcome measure for assessing and addressing bowel urgency in clinical settings.
H. pylori is the most common cause of chronic gastritis. However, the antibiotic resistance of various strains is the main reason for the failure of eradication therapy. This requires pre-therapeutic antibiotic susceptibility testing.
Curing malignant melanoma with a faecal transplant may sound far-fetched, but new study results show the potential of microorganisms.