• Displaying calories on restaurant menus: scenarios for the UK

    Over 9,000 heart disease deaths could be avoided by 2041 in England if all gastronomy establishments displayed calorie disclaimers on their menus.

  • Patient Perspectives of Bowel Urgency and Bowel Urgency-Related Accidents in Ulcerative Colitis and Crohn’s Disease

    Bowel urgency and bowel urgency-related accidents are accompanied by several bothersome symptoms and considerably impact patients’ quality of life, highlighting the need to develop a patient-reported outcome measure for assessing and addressing bowel urgency in clinical settings.

  • Concerns over increasing antibiotic resistance of Helicobacter pylori: Is it time for new guidelines?

    H. pylori is the most common cause of chronic gastritis. However, the antibiotic resistance of various strains is the main reason for the failure of eradication therapy. This requires pre-therapeutic antibiotic susceptibility testing.

  • Microbiota as a therapeutic option: not only in gastroenterology

    Curing malignant melanoma with a faecal transplant may sound far-fetched, but new study results show the potential of microorganisms.

  • Meeting the global protein supply requirements of a growing and ageing population

    There is a growing consensus that older people have a greater requirement for protein. With a larger and older population, global needs for protein are set to increase. This paper summarises the conclusions from a Rank Prize funded colloquium evaluating novel strategies to meet this increasing global protein need.

  • Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses

    The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373). Overall, direct associations were found between exposure to ultra-processed foods and 32 (71%) health parameters spanning mortality, cancer, and mental, respiratory, cardiovascular, gastrointestinal, and metabolic health outcomes.

  • Approaching Digestive Health Care in Transgender and Gender-Diverse Communities

    Transgender and gender-diverse (TGD) people are more likely than cisgender people to experience adverse health outcomes and health care discrimination. These disparities remain uninvestigated in gastroenterology (GI) and hepatology. Here, we describe what is known about digestive clinical care in TGD people. Practical considerations are offered to assist in the provision of culturally humble care to TGD people.

  • An ingestible self-propelling device for intestinal reanimation

    Here, we developed an ingestible self-propelling device for intestinal reanimation (INSPIRE) capable of restoring peristalsis through luminal electrical stimulation. Optimizing mechanical, material, and electrical design parameters, we validated optimal deployment, intestinal electrical luminal contact, self-propelling capability, safety, and degradation of the device in ex vivo and in vivo swine models.

  • A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study

    The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and to develop a high-accuracy prediction tool. The analysis included 8254 cases of acute hematochezia patients who were admitted urgently based on the judgment of emergency physicians or gastroenterology consultants (from the CODE BLUE J-study).

  • Constipated patients with functional defecatory disorder have secondary rectal hyposensitivity due to altered rectal biomechanics

    The aim is to evaluate the relationship between RH (measured by the RBB) and FDD (defined as any minor disorder of rectoanal coordination by the London classification) in constipated patients.

  • Comparison of Fecal Calprotectin and Myeloperoxidase in Predicting Outcomes in Inflammatory Bowel Disease

    This study investigated the utility of neutrophil biomarkers fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) in predicting a complicated IBD course.

  • Heartburn: Can alkaline mineral water help?

    Many people regularly suffer from heartburn, and look for relief in medications. A recent study checked if mineral water containing bicarbonate can also improve symptoms.

  • Burgers, fries, pizzas: "only once" is not enough

    People occasionally treat themselves to a cheat day, a day of indulging in unhealthy food and drink. But even infrequent consumption leaves a mark.

  • Undiagnosed Cirrhosis and Hepatic Encephalopathy in a National Cohort of Veterans With Dementia

    In this cohort study including 177 422 veterans with a diagnosis of dementia, a high Fibrosis-4 score suggestive of advanced liver fibrosis to cirrhosis was observed in 5% to 10% of the patients who previously did not have a diagnosis of cirrhosis. These findings were supported by 2 validation cohorts within the Richmond VA Medical Center.

  • Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer

    In this review, we summarize the data behind the relationship of CRC in post-appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix.

  • Risk factors for gastroesophageal reflux disease: a population-based study

    Based on the results, smoking, alcohol, inactivity, high intake of sweets and desserts, low intake of fiber, depression, visceral fat, and obesity are considered as risk factors for GERD. Modifying lifestyle and behavioral habits prevent GERD.

  • A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy

    We analyzed 52 biomarkers on 1,710,973 spatially resolved single cells to determine cell types, cell-cell contacts, and cellular neighborhoods. We observed that cellular functional states are associated with cellular neighborhoods.

  • Global burden and risk factors of gastritis and duodenitis: an observational trend study from 1990 to 2019

    Using the global burden of disease (GBD) database spanning 1990 to 2019, we evaluated the temporal trends of age-standardized incidence rates (ASIR), age-standardized death rates (ASDR), and age-standardized disability-adjusted life years (AS-DALYs) for GD using estimated annual percentage changes (EAPC).

  • Thirty-Day Readmissions Are Largely Not Preventable in Patients With Cirrhosis

    Of 654 patients, 246 (38%) were readmitted, and 29 (12%) were preventable readmissions. Reviewers agreed on preventability for 70% of readmissions. Twenty-two (including 2 with preventable readmission) died.

  • Using biomarkers in Crohn's disease

    New guidelines highlight the reliability of blood and faecal tests to monitor inflammation degrees in CD, thus reducing invasive endoscopy frequencies.

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