• Microbiome mapping in dairy industry reveals new species and genes for probiotic and bioprotective activities

    Although microbial pathogens were not prevalent, we found several MAGs harboring genes related to antibiotic resistance, highlighting that dairy industry surfaces represent a potential hotspot for antimicrobial resistance (AR) spreading along the food chain.

  • Interview: The future of gastrointestinal oncology

    This interview after the 'ESMO GI Cancers 2024' congress was an opportunity for in-depth study and discussion of new developments in GI oncology.

  • Treating GI tumours in geriatric patients

    Gastrointestinal tumours occur most frequently in people over 70. But how does the treatment of geriatric patients differ from that of younger patients?

  • Can aspirin prevent cancer?

    Long-term daily aspirin intake may help prevent colorectal cancer development and progression but the mechanisms involved are still unclear.

  • Salmonella infection: is tomato juice a treatment option?

    Could bacteria or viruses be rendered harmless by tomatoes or its products? Researchers investigated if tomato substances work against S. typhi.

  • Colon carcinoma: current biomarker tools and new developments

    Precision medicine is revolutionising treatments for colon cancer and other gastrointestinal malignancies by identifying biomarkers for personalised therapies.

  • Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies

    Gastrointestinal biofilms are highly heterogenic and spatially organized polymicrobial communities that can expand and cover large areas in the gastrointestinal tract.

  • Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis

    Glycolysis in HSCs amplifies liver fibrosis by promoting fibrogenic EV release in the hepatic pericentral zone, which represents a potential therapeutic target.

  • Routine upper gastro-intestinal tract endoscopy before elective cholecystectomy for symptomatic gallstones-justified

    The practice of routine UGI endoscopy before elective cholecystectomy has been justified by the finding of active UGI pathology which warranted treatment in a significant proportion of patients with presumed symptomatic gallstones in an African setting.

  • Prevalence of small intestinal bacterial overgrowth in intestinal failure syndrome: A systematic review and meta-analysis

    This systematic review and meta-analysis suggests that there is an increased risk of SIBO in patients with IF and that PN, and potentially, the use of PPI/acid-suppressing agents is risk factors for SIBO development in patients with IF.

  • Prospective Validation of a Prediction Model for the Diagnosis of Acute Pancreatitis

    In this diagnostic study validating a prediction model, the model demonstrated excellent accuracy. At a score of at least 6 points, prediction model accuracy and performance were optimized, serious alternative diagnoses were uncommon, and diagnostic yield of early imaging was low.

  • Food Insecurity, Low Household Income, and Low Education Level Increase the Risk of Having Metabolic Dysfunction–Associated Fatty Liver Disease Among Adolescents in the United States

    The prevalence of MASLD was greater among food-insecure adolescents vs food-secure ones (17.4% vs 9.4%) and adolescents living with a low HH income vs those with a higher HH income (15.0% vs 7.2%) and living with a head of HH with a lower education level vs one with a higher education level (18.0% vs 8.2%) (P < 0.05).

  • Solute Transporter OCTN1/Slc22a4 Affects Disease Severity and Response to Infliximab in Experimental Colitis: Role of Gut Microbiota and Immune Modulation

    Our data support the murine model to study OCTN1 genetic contribution to inflammatory bowel diseases. This could be the first step towards the recognition of this membrane transporter as a biomarker in inflammatory conditions and a predictor of response to therapies.

  • Beans: powerful supporters in colorectal cancer aftercare

    The intestinal microbiome is essential in many body processes. Could prebiotic food intake benefit intestinal flora in intestinal polyps or colorectal carcinoma?

  • Reflux in infants does not usually require treatment

    Gastro-oesophageal reflux and regurgitation often cause parental concern, but only few babies have a pathology that requires treatment.

  • Systematic review and meta-analysis of endoscopic versus medical management of peptic ulcers with adherent clots

    There was evidence for a reduction in recurrent bleeding from peptic ulcers with adherent clots treated with endoscopic hemostatic techniques compared with medical management alone but no difference in rates of mortality or need for surgery.

  • Robotic wireless capsule endoscopy: recent advances and upcoming technologies

    This Review discusses the future requirements for intelligent capsule robots, providing a comparative evaluation of various methods’ merits and disadvantages, and highlighting recent developments in six technologies relevant to WCE.

  • Helicobacter pylori Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer

    The findings of this cohort study indicate that a high genetic risk of GC may be counteracted by H pylori treatment, suggesting primary prevention could be tailored to genetic risk for more effective prevention.

  • Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B

    Among the four noninvasive models, GPR has the best performance in the diagnosis of hepatic fibrosis in CHB patients and is more valuable in HBeAg-positive patients.

  • Deciphering the clinical spectrum of gastric disease in patients with Juvenile Polyposis Syndrome

    Clinical, endoscopic, genetic, pathological data from patients with SMAD4 or BMPR1A PVs included between 2007 and 2020 in the French network on rare digestive polyposis (RENAPOL) database were prospectively collected to address uncertainties regarding gastric involvement.

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