• Burden of perianal disease in Crohn's disease: Accelerating medical therapy and high rates of perianal surgery over the last four decades – Results from a population-based study over four decades

    The burden of perianal disease and perianal surgery rates were high in this cohort. Therapeutic strategy was accelerated in patients with perianal Crohn's over time with higher exposure to immunosuppressives and biologics.

  • A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety

    In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension.

  • The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

    Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk.

  • Exposure to Agent Orange and Hepatocellular Carcinoma Among US Military Personnel

    Is Agent Orange (AO) exposure during the Vietnam War (1966 to 1975) associated with incident hepatocellular carcinoma (HCC)? These findings suggest that AO exposure is not associated with incident HCC.

  • The Epidemiology of Inflammatory Bowel Disease in Oceania: A Systematic Review and Meta-Analysis of Incidence and Prevalence

    This systematic review and meta-analysis of inflammatory bowel disease in Oceania found high incidence rates (19.8 [95% confidence interval, 15.8-23.7] per 100 000 person-years) and prevalence rates (303.3 [95% confidence interval, 128.1-478.4] per 100 000 persons).

  • Liver diseases are being renamed: an end to stigmatisation?

    The terms non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are misleading for some experts, with inaccurate associations leading to stigmas.

  • Can Alzheimer's be detected in the gut microbiome before cognitive impairment appears?

    An altered gut microbiome may precede the clinical signs of Alzheimer's disease. Can the gut microbiome be used as an early biomarker?

  • International survey on complications of religious fasting after metabolic and bariatric surgery

    Patients after MBS should be advised about the risks while fasting including abdominal pain, dehydration, and peptic ulcer disease exacerbation, and a thorough review of their medications is warranted to minimize complications.

  • The use of fully covered self-expandable metal stents in the endoscopic treatment of portal cavernoma cholangiopathy

    FCSEMS placement is an effective method in biliary strictures in case of PCC. Acute cholecystitis is encountered frequently after FCSEMS, but majority of patients respond to the medical treatment.

  • Classification and Management of Disorders of the J Pouch

    For the purpose of this review, we focused on the diagnosis of some of the most common inflammatory and structural pouch disorders and their respective management. Pouchitis is the most common complication, and it is typically responsive to antibiotics.

  • The Crohn’s Disease Exclusion Diet: A Comprehensive Review of Evidence, Implementation Strategies, Practical Guidance, and Future Directions

    The CDED has emerged as a valid alternative to EEN with cumulative evidence, including randomized controlled trials, supporting use for induction of remission and possibly maintenance in children and adults.

  • Cost-Effectiveness of Blood-Based Biomarkers for Colorectal Cancer Screening - An Ounce of Prevention Is Worth a Pound of Cure

    There are several timely, important, and novel aspects to colorectal cancer (CRC) screening that are highlighted in the study by Aziz et al.

  • Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the EPIC study

    During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. UPF consumption was positively associated with accidental death in the negative control analysis.

  • Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a

    Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR.

  • 5 abstracts awarded at UEG WEEK 2023

    The annual international congress took place as a hybrid event in Copenhaguen and online during 14-16 October with over 11,000 participants.

  • Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for intervention

    Ultra-processed foods, sugar sweetened beverages, and saturated fats are the main contributors; dietary patterns, such as the Mediterranean diet, could be the best prevention

  • Amitriptyline helps relieve IBS symptoms

    The results showed that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.

  • Sex- and reproductive status-specific relationships between body composition and non-alcoholic fatty liver disease

    Increased WC and low FFM/FM in men and visceral obesity in post-menopausal women were independent correlates of more severe liver steatosis.

  • Working With Indigenous Community and Patient Partners Is Essential to Advance Research: Perspectives From Canada

    We recommend 5 steps for engaging with Indigenous community members to build meaningful and respectful relationships and co-create Indigenous gastroenterology and hepatology knowledge.

  • Ultra-processed foods and cardiometabolic health: public health policies to reduce consumption cannot wait

    Existing evidence is sufficiently strong to warrant immediate public health actions to help citizens identify ultra-processed foods and limit their exposure.

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