• Early gastric cancer detection and lesion segmentation based on deep learning and gastroscopic images

    The results demonstrate that IMR-CNN exhibits superior accuracy compared to MR-CNN in both EGC detection and lesion segmentation. To enhance the robustness of the findings, a rigorous fivefold cross-validation was performed on a self-built dataset, verifying the reliability of the models.

  • Anti–Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy

    In this cohort study of 1293 patients, the anti–H pylori treatment group had a significant survival advantage compared with the non–anti–H pylori treatment group in terms of overall survival and disease-free survival. After propensity score matching, the survival advantage for both overall and disease-free survival remained.

  • Prescribing in pregnant women with inflammatory bowel disease and its relationship to congenital malformations in Japan

    This study provides insights into medication patterns in pregnant IBD patients and suggests no increased risk of MCMs associated with first-trimester IBD medication use.

  • Displaying calories on restaurant menus: scenarios for the UK

    Over 9,000 heart disease deaths could be avoided by 2041 in England if all gastronomy establishments displayed calorie disclaimers on their menus.

  • Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance

    Antibiotic resistance is one of the main factors that determine the efficacy of treatments to eradicate Helicobacter pylori infection. Our aim was to evaluate the effectiveness of first-line and rescue treatments against H. pylori in Europe according to antibiotics resistance.

  • Patient Perspectives of Bowel Urgency and Bowel Urgency-Related Accidents in Ulcerative Colitis and Crohn’s Disease

    Bowel urgency and bowel urgency-related accidents are accompanied by several bothersome symptoms and considerably impact patients’ quality of life, highlighting the need to develop a patient-reported outcome measure for assessing and addressing bowel urgency in clinical settings.

  • Concerns over increasing antibiotic resistance of Helicobacter pylori: Is it time for new guidelines?

    H. pylori is the most common cause of chronic gastritis. However, the antibiotic resistance of various strains is the main reason for the failure of eradication therapy. This requires pre-therapeutic antibiotic susceptibility testing.

  • Microbiota as a therapeutic option: not only in gastroenterology

    Curing malignant melanoma with a faecal transplant may sound far-fetched, but new study results show the potential of microorganisms.

  • Meeting the global protein supply requirements of a growing and ageing population

    There is a growing consensus that older people have a greater requirement for protein. With a larger and older population, global needs for protein are set to increase. This paper summarises the conclusions from a Rank Prize funded colloquium evaluating novel strategies to meet this increasing global protein need.

  • Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses

    The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373). Overall, direct associations were found between exposure to ultra-processed foods and 32 (71%) health parameters spanning mortality, cancer, and mental, respiratory, cardiovascular, gastrointestinal, and metabolic health outcomes.

  • Approaching Digestive Health Care in Transgender and Gender-Diverse Communities

    Transgender and gender-diverse (TGD) people are more likely than cisgender people to experience adverse health outcomes and health care discrimination. These disparities remain uninvestigated in gastroenterology (GI) and hepatology. Here, we describe what is known about digestive clinical care in TGD people. Practical considerations are offered to assist in the provision of culturally humble care to TGD people.

  • An ingestible self-propelling device for intestinal reanimation

    Here, we developed an ingestible self-propelling device for intestinal reanimation (INSPIRE) capable of restoring peristalsis through luminal electrical stimulation. Optimizing mechanical, material, and electrical design parameters, we validated optimal deployment, intestinal electrical luminal contact, self-propelling capability, safety, and degradation of the device in ex vivo and in vivo swine models.

  • A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study

    The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and to develop a high-accuracy prediction tool. The analysis included 8254 cases of acute hematochezia patients who were admitted urgently based on the judgment of emergency physicians or gastroenterology consultants (from the CODE BLUE J-study).

  • Constipated patients with functional defecatory disorder have secondary rectal hyposensitivity due to altered rectal biomechanics

    The aim is to evaluate the relationship between RH (measured by the RBB) and FDD (defined as any minor disorder of rectoanal coordination by the London classification) in constipated patients.

  • Comparison of Fecal Calprotectin and Myeloperoxidase in Predicting Outcomes in Inflammatory Bowel Disease

    This study investigated the utility of neutrophil biomarkers fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) in predicting a complicated IBD course.

  • Heartburn: Can alkaline mineral water help?

    Many people regularly suffer from heartburn, and look for relief in medications. A recent study checked if mineral water containing bicarbonate can also improve symptoms.

  • Burgers, fries, pizzas: "only once" is not enough

    People occasionally treat themselves to a cheat day, a day of indulging in unhealthy food and drink. But even infrequent consumption leaves a mark.

  • Undiagnosed Cirrhosis and Hepatic Encephalopathy in a National Cohort of Veterans With Dementia

    In this cohort study including 177 422 veterans with a diagnosis of dementia, a high Fibrosis-4 score suggestive of advanced liver fibrosis to cirrhosis was observed in 5% to 10% of the patients who previously did not have a diagnosis of cirrhosis. These findings were supported by 2 validation cohorts within the Richmond VA Medical Center.

  • Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer

    In this review, we summarize the data behind the relationship of CRC in post-appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix.

  • Risk factors for gastroesophageal reflux disease: a population-based study

    Based on the results, smoking, alcohol, inactivity, high intake of sweets and desserts, low intake of fiber, depression, visceral fat, and obesity are considered as risk factors for GERD. Modifying lifestyle and behavioral habits prevent GERD.

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