There is a growing consensus that older people have a greater requirement for protein. With a larger and older population, global needs for protein are set to increase. This paper summarises the conclusions from a Rank Prize funded colloquium evaluating novel strategies to meet this increasing global protein need.
The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373). Overall, direct associations were found between exposure to ultra-processed foods and 32 (71%) health parameters spanning mortality, cancer, and mental, respiratory, cardiovascular, gastrointestinal, and metabolic health outcomes.
Transgender and gender-diverse (TGD) people are more likely than cisgender people to experience adverse health outcomes and health care discrimination. These disparities remain uninvestigated in gastroenterology (GI) and hepatology. Here, we describe what is known about digestive clinical care in TGD people. Practical considerations are offered to assist in the provision of culturally humble care to TGD people.
Here, we developed an ingestible self-propelling device for intestinal reanimation (INSPIRE) capable of restoring peristalsis through luminal electrical stimulation. Optimizing mechanical, material, and electrical design parameters, we validated optimal deployment, intestinal electrical luminal contact, self-propelling capability, safety, and degradation of the device in ex vivo and in vivo swine models.
The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and to develop a high-accuracy prediction tool. The analysis included 8254 cases of acute hematochezia patients who were admitted urgently based on the judgment of emergency physicians or gastroenterology consultants (from the CODE BLUE J-study).
The aim is to evaluate the relationship between RH (measured by the RBB) and FDD (defined as any minor disorder of rectoanal coordination by the London classification) in constipated patients.
This study investigated the utility of neutrophil biomarkers fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) in predicting a complicated IBD course.
Many people regularly suffer from heartburn, and look for relief in medications. A recent study checked if mineral water containing bicarbonate can also improve symptoms.
People occasionally treat themselves to a cheat day, a day of indulging in unhealthy food and drink. But even infrequent consumption leaves a mark.
In this cohort study including 177 422 veterans with a diagnosis of dementia, a high Fibrosis-4 score suggestive of advanced liver fibrosis to cirrhosis was observed in 5% to 10% of the patients who previously did not have a diagnosis of cirrhosis. These findings were supported by 2 validation cohorts within the Richmond VA Medical Center.
In this review, we summarize the data behind the relationship of CRC in post-appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix.
Based on the results, smoking, alcohol, inactivity, high intake of sweets and desserts, low intake of fiber, depression, visceral fat, and obesity are considered as risk factors for GERD. Modifying lifestyle and behavioral habits prevent GERD.
We analyzed 52 biomarkers on 1,710,973 spatially resolved single cells to determine cell types, cell-cell contacts, and cellular neighborhoods. We observed that cellular functional states are associated with cellular neighborhoods.
Using the global burden of disease (GBD) database spanning 1990 to 2019, we evaluated the temporal trends of age-standardized incidence rates (ASIR), age-standardized death rates (ASDR), and age-standardized disability-adjusted life years (AS-DALYs) for GD using estimated annual percentage changes (EAPC).
Of 654 patients, 246 (38%) were readmitted, and 29 (12%) were preventable readmissions. Reviewers agreed on preventability for 70% of readmissions. Twenty-two (including 2 with preventable readmission) died.
New guidelines highlight the reliability of blood and faecal tests to monitor inflammation degrees in CD, thus reducing invasive endoscopy frequencies.
Data demonstrate that the anti-CD40 colitis model shows key features of IBD observed in the human disease, hence making it a suitable model to investigate the pathophysiology of ulcerative colitis (UC).
Who thinks instantly of bowel cancer when abdominal pain or diarrhoea hits? It turns out, these complaints may be key symptoms of early colorectal cancer.
A preclinical study highlights the potential of SIWA318H, an antibody targeting advanced glycation end-products, in the fight against pancreatic cancer.
The acute aspirin challenge significantly increased intestinal permeability similarly in both groups, and prophylactic probiotic consumption was unable to prevent the loss in this particular model.