• Global safety report: more VTE events on JAK inhibition in rheumatoid arthritis

    A register study explored worldwide data on MACEs and venous thromboembolism associated with JAK inhibitors compared to anti-TNF agents in RA.

  • My DNA: Where Did My Ancestors Come From? (Part 2)

    Prof. Dr. Reinhard Renneberg uses his own DNA as an example to show which migratory routes his earliest ancestors took.

  • Antifibrotic therapy effective in patients with negative lung function prognostics

    A post-hoc trial analysis revealed nintedanib treatment benefit in patients with 4 characteristics associated with a fast decline in lung function.

  • Steep increase of mortality in RA patients with comorbid depression

    A large register study in Denmark detected a substantially higher mortality risk for patients with rheumatoid arthritis (RA) who had comorbid depression.

  • TYK2 inhibition: A rising star in lupus therapy?

    Deucravacitinib showed convincing results as a treatment for patients with active systemic lupus erythematosus (SLE) in the phase 2 PAISLEY trial.

  • RA: Several risk factors identified for incident dementia

    Cohort study data detected factors linked to a risk amplification for dementia development in patients with rheumatoid arthritis.

  • Baricitinib shows great potential in juvenile idiopathic arthritis

    During the double-blind period of a withdrawal trial, baricitinib demonstrated predominance over placebo in the prevention of disease flares.

  • JAK inhibitor shows to be effective in non-radiographic axSpA

    Once-daily therapy with upadacitinib led to an ASAS40 response in 45% of patients with active nr-axSpA at week 14 in the SELECT-AXIS-2 trial.

  • Prof. Lorenzo Brunetti: Artificial intelligence and ethical dilemmas in hematology

    esanum talks with Prof. Brunetti about AI in medicine, its ethical implications and physicians' approach to this tech revolution.

  • DA-EPOCH-R: less toxic than CODOX-M/R-IVAX in high-risk Burkitt lymphoma

    Trial results show equal DA-EPOCH-R efficacy to CODOX-M/R-IVAX as first-line treatment in patients, but less toxicity.

  • Prof. Antonio Almeida: Academic knowledge disseminates in no time

    New technologies have transformed haematology. Gene-editing and molecular agents become available to patients within shorter timeframes.

  • Can ACE Inhibitors Help Prevent Renal Crisis in Scleroderma?

    A Chinese meta-analysis of studies on the treatment of scleroderma has investigated whether ACE inhibitors can be used to prevent renal crisis.

  • Prof. Maria Chiara Bonini: Gene therapy applied to immunotherapy

    esanum talks with Prof. Bonini about her research projects, her EHA board role and the prospects for young hematologists who wish to engage in research.

  • PI3Kδ inhibitor leniolisib improves symptoms in patients with APDS/PASLI

    Leniolisib is safe, increases naïve B cells, decreases lymphadenopathy and spleen size, and improves cytopenia in APDS/PASLI.

  • Early ASCT to triplet therapy improves PFS in multiple myeloma

    Early ASCT in lenalidomide / bortezomib / dexamethasone therapy followed by lenalidomide maintenance, significantly improves PFS for newly diagnosed MM

  • Single-dosed exa-cel leads to early and durable increase of foetal haemoglobin

    Exa-cel gene-editing therapy is associated with increase in foetal and total Hb in transfusion-dependent β-thalassemia or severe sickle cell disease patients.

  • Triple-therapy improves PFS in fit, previously untreated CLL patients

    Phase-3 trial shows improved PFS with venetoclax/obinutuzumab/ibrutinib therapy in fit, untreated patients with chronic lymphocytic leukaemia.

  • Hack Your Care opens the doors to innovation in health

    A new platform connects the spheres of medical care and health innovation. It allows caregivers to find assignments with innovation actors, including companies.

  • No survival benefit of CPX-351 over FLAG-Ida in AML patients with adverse cytogenetics

    CPX-351 does not improve response, overall survival, or event-free survival compared with FLAG-Ida in AML patients with adverse cytogenetics.

  • Luspatercept benefits transfusion-dependent β-thalassemia patients after 3 years

    Continued treatment with luspatercept, for up to 3 years, allowed more patients to experience a reduction in red blood cell transfusion burden.

  • 31 |
  • 32 |
  • 33 |
  • 34 |
  • 35 |
  • 36 |
  • 37 |
  • 38 |
  • 39 |
  • 40 |
  • 41 |