Large-scale whole-genome sequencing, whole-exome sequencing, and RNA-expression profiling found new T-cell acute lymphoblastic leukaemia subtypes.
OS improves when combined with standard induction and consolidation therapy, and as continuation therapy as a single agent for up to 3 years in patients.
A subgroups analysis of patients aged 65 years or older in ZUMA-7 demonstrated axi-cel to be superior to standard-of-care for second-line treatment.
Post-trial data support caplacizumab's long-term safety and efficacy in acquired or immune-mediated thrombotic thrombocytopenic purpura patients.
Nivolumab and radiotherapy at a single lesion is well tolerated and leads to an abscopal response in most of relapsed/refractory HL cases.
The phase 3 MOMENTUM trial show a significant improvement in symptoms, spleen size, and anaemia measures with momelotinib over danazol.
Phase-3 ATLAS trial shows the post-transplant maintenance therapy benefit of carfilzomib, lenalidomide, and dexamethasone over lenalidomide.
AML has high patient-to-patient treatment response variability. Pharmacoscopy allows ex vivo drug-response profiling of tumour cells, enabling tailored treatments.
In 1983 and 1986, the British police struggle with two murders. Until geneticist Dr. Alec Jeffreys brought us RFLP. Genetic fingerprinting was born.
After third-line failure, a 61-year-old female patient with metastatic pancreatic ductal adenocarcinoma received off-label monotherapy with olaparib.
OVer two years into the pandemic, a global emergency medicine professionals survey reveals that 62% reported one or more COVID-19-related burnout symptoms.
The human eye has immunological peculiarities. The graft rejection rate, for example, is just 10%. For non-vascularised corneas only about 2%.
A Spanish-German team of scientists may have made a breakthrough in the search for a reliable screening method for pancreatic cancer.
Patients without statins or lipid-lowering drugs tolerance have few options to lower LDL. Researchers developed a snack that reduced LDL cholesterol by up to 40%.
A health insurance association and a divided committee found no extra benefits in a proposed peanut-based protein treatment for children and adolescents.
A study identified markers in chronic lymphatic leukaemia associated with the risk of Richter syndrome, or progression of leukaemia into an aggressive lymphoma.
Medical app found to benefit type 1 diabetes children in hybrid close-loop systems via glucose values measurement for insulin pump control.
A large observational study of infants with sepsis shows the impact antimicrobial resistance is having on this vulnerable population.
Almost single-handedly, a trainee doctor brought medical aid worth more than € 50,000 to Kiev. How does he assess this spontaneous initiative?
Older men often suffer from erectile dysfunction. After urological clarification, they are often treated long-term with PDE-5 inhibitors. This can literally, backfire.